[关键词]
[摘要]
目的 观察西地碘含片联合聚维酮碘治疗牙周炎的临床效果。方法 选择2017年1月-2018年12月在河南省省直第二医院治疗的型牙周炎患者149例,随机分成对照组(74例)和治疗组(75例)。对照组牙周袋冲洗聚维酮碘溶液。治疗组在对照组治疗基础上含服西地碘含片,1.5 mg/次,3次/d。两组患者均连续治疗2周。观察两组患者临床疗效,同时比较治疗前后两组患者C反应蛋白(CRP)、可溶性黏附分子1(sICAM-1)、白介素-10(IL-10)、牙菌斑指数(PLI)、牙龈指数(GI)和龈沟出血指数(SBI)水平。结果 治疗后,对照组临床有效率为79.76%,显著低于治疗组的89.76%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者CRP、sICAM-1、PLI、GI和SBI水平均显著降低(P<0.05),而IL-10水平均显著升高(P<0.05),且治疗后治疗组患者这些指标水平改善效果明显优于对照组(P<0.05)。结论 西地碘含片联合聚维酮碘治疗牙周炎,可明显改善患者临床症状,缓解机体炎症反应水平,改善牙周情况。
[Key word]
[Abstract]
Objective To observe the clinical effect of Cydiodine Buccal Tablets combined with povidone iodine in Treatment of periodontitis. Methods Patients (149 cases) with periodontitis in the Second Hospital Directly under the Authority of Henan from January 2017 to December 2018 were randomly divided into control (74 cases) and treatment (75 cases) groups. Patients in the control group were periodontal pocket irrigation administered with Povidone Iodine Solution. Patients in the treatment group were po administered with Cydiodine Buccal Tablets on the basis of the control group, 1.5 mg/time, three times daily. Patients in two groups were treated for 2 weeks. After treatment, the clinical efficacy was evaluated, and the level of CRP, sICAM-1, IL-10, PLI, GI and SBI in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 79.76%, which was significantly lower than 89.76% in the treatment group, and there were differences between two groups (P<0.05). After treatment, the level of CRP, sICAM-1, PLI, GI and SBI in two groups was significantly decreased (P<0.05), but the IL-10 level was significantly increased (P<0.05), and these indicators in the treatment group were significantly better than those in the control group (P<0.05). Conclusion Cydiodine Buccal Tablets combined with povidone iodine in Treatment of periodontitis can obviously improve the clinical symptoms, relieve the level of inflammatory reaction, and improve the gum condition.
[中图分类号]
R988.2
[基金项目]