目的 研究胰胆舒颗粒联合注射用兰索拉唑治疗急性胰腺炎的临床疗效。方法 选取2018年12月-2019年12月郑州大学附属洛阳中心医院收治的100例急性胰腺炎患者为研究对象，将所有患者随机分为对照组和治疗组，每组各50例。对照组患者静脉注射注射用兰索拉唑，30 mg溶于0.9%氯化钠注射液100 mL中，2次/d。治疗组在对照组基础上口服胰胆舒颗粒，10 g/次，3次/d。两组患者持续治疗10 d。观察两组患者临床疗效，比较两组的临床症状缓解时间、胰腺炎床旁严重度指数（BISAP）评分、血清学指标、血清炎性因子水平。结果 治疗后，治疗组总有效率94.00%，显著高于对照组的80.00%（P<0.05）。治疗后，治疗组排气恢复正常时间、腹水消失时间、血淀粉酶恢复正常时间、排气恢复正常时间、腹痛消失时间、尿淀粉酶恢复正常时间明显短于对照组（P<0.05）。治疗后，两组胰腺炎床旁严重度指数（BISAP）评分显著降低（P<0.05）；并且治疗组BISAP评分降低较明显（P<0.05）。治疗后，两组血清淀粉酶（AMS）、脂肪酶（LPS）水平显著降低（P<0.05）；并且治疗组血清AMS、LPS水平明显低于对照组（P<0.05）。治疗后，两组患者血清肿瘤坏死因子-α（TNF-α）、C反应蛋白（CRP）和白细胞介素-6（IL-6）水平显著降低（P<0.05）；并且治疗组血清TNF-α、CRP和IL-6水平明显低于对照组（P<0.05）。结论 胰胆舒颗粒联合注射用兰索拉唑治疗急性胰腺炎具有较好的治疗效果，能够改善临床症状，降低血清AMS和LPS、炎性因子水平，值得在临床上推广应用。

Objective To study the effect of Yidanshu Granules combined with Lansoprazole for injection in treatment of acute pancreatitis. Methods Patients (100 cases) with acute pancreatitis in Luoyang Central Hospital Affiliated to Zhengzhou University from December 2018 to December 2019 were randomly divided into control and treatment groups, and each group had 50 cases. Patients in the control group were iv administered with Lansoprazole for injection, 30 mg added into 0.9% sodium chloride injection 100 mL, twice daily. Patients in the treatment group were po administered with Yidanshu Granules on the basis of the control group, 10 g/time, three times daily. Patients in two groups were treated for 10 d. After treatment, the clinical efficacies were evaluated, and the remission time of clinical symptom, the BISAP score, the serological index, and the serum inflammatory factor in two groups were compared. Results After treatment, the total effective rate of the treatment group was 94.00%, which was significantly higher than that of the control group (80.00%) (P<0.05). After treatment, the recovery time of exhaust, ascites, blood amylase, exhaust, abdominal pain and urine amylase in the treatment group were significantly shorter than those in the control group (P<0.05). After treatment, the BISAP scores of two groups was significantly decreased (P<0.05), and BISAP score of the treatment group was significantly lower than that of the control group (P<0.05). After treatment, the serum levels of AMS and LPS in the two groups were significantly decreased (P<0.05), and the serum levels of AMS and LPS in the treatment group were significantly lower than those in the control group (P<0.05). After treatment, the serum levels of TNF-α, CRP, and IL-6 in the two groups were significantly decreased (P<0.05), and the serum inflammatory factor levels in the treatment group were lower than those in the control group (P<0.05). Conclusion Yidanshu Granules combined with Lansoprazole for injection has clinical curative effect in treatment of acute pancreatitis, can improve clinical symptoms, reduce serum levels of AMS, LPS, and inflammatory factors, which is worthy of clinical application.

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