目的 研究苏黄止咳胶囊联合丙酸倍氯米松气雾剂治疗慢性支气管炎急性发作期的临床疗效。方法 选取2018年4月-2019年4月在平煤神马医疗集团总医院治疗的140例慢性支气管炎急性发作期患者，所有患者随机分为对照组和治疗组，每组各70例。对照组患者给予丙酸倍氯米松气雾剂，2揿/鼻孔，2次/d。治疗组在对照组基础上给予苏黄止咳胶囊，3粒/次，3次/d。两组患者持续治疗14 d。观察两组患者临床疗效，比较两组的临床症状缓解时间、血清炎性指标水平、肺功能指标、支气管炎的严重程度（BSS）评分。结果 治疗后，治疗组总有效率（95.71%）显著高于对照组（84.29%）（P<0.05）。治疗后，治疗组咳痰、咳嗽、发热、肺部啰音消退时间明显短于对照组（P<0.05）。治疗后，两组血清白细胞介素（IL）-8、肿瘤坏死因子（TNF）-α、超敏C反应蛋白（hs-CRP）水平显著降低（P<0.05）；并且治疗组血清炎性因子水平降低较多（P<0.05）。治疗后，两组患者第1秒用力呼气容积（FEV₁）、峰值呼气流速（PEF）和FEV₁/用力肺活量（FVC）显著升高（P<0.05），且治疗组肺功能指标升高较多（P<0.05）。治疗后，两组BSS评分显著降低（P<0.05）；并且治疗组BSS评分降低较多（P<0.05）。结论 苏黄止咳胶囊联合丙酸倍氯米松气雾剂治疗慢性支气管炎急性发作期具有较好的临床疗效，能够改善患者肺功能和临床症状，降低血清炎性因子水平，值得在临床上推广应用。

Objective To study the efficacy of Suhuang Zhike Capsules combined with beclomethasone propionate in treatment of acute episode of chronic bronchitis. Methods Patients (140 cases) with acute episode of chronic bronchitis in Pingmei Shenma Medical Group General Hospital from April 2018 to April 2019 were randomly divided into control and treatment groups, and each group had 70 cases. Patients in the control group were given Beclometasone Dipropionate Aerosol, 2 press/nostril, twice daily. Patients in the treatment group were po administered with Suhuang Zhike Capsules on the basis of the control group, 3 grains/time, three times daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacies were evaluated, and clinical symptom relief time, serum level of inflammatory indexes, pulmonary function index, and BSS score in two groups were compared. Results After treatment, the total effective rate of the treatment group (95.71%) was significantly higher than that of the control group (84.29%) (P<0.05). After treatment, resolution times of expectoration, cough, fever, and lung rales in the treatment group were significantly shorter than those in the control group (P<0.05). After treatment, the levels of IL-8, TNF-α, and hs-CRP in two groups were significantly decreased (P<0.05); and the indexes in the treatment group were significantly lower than those in the control group (P<0.05). After treatment, FEV₁, PEF, and FEV₁/FVC in two groups were significantly increased (P<0.05); and the indexes in the treatment group were significantly higher than those in the control group (P<0.05). Conclusion Suhuang Zhike Capsules combined with beclomethasone propionate has clinical curative effect in treatment of acute episode of chronic bronchitis, can improve pulmonary function and clinical symptoms of patients, reduce the serum level of inflammatory factors, which is worthy of clinical application.

R974