目的 探讨野木瓜片联合苯妥英钠片治疗三叉神经痛的临床疗效。方法 选择2018年5月-2019年5月在天津医科大学第二医院治疗的三叉神经痛患者84例，根据用药的差别分为对照组（42例）和治疗组（42例）。对照组口服苯妥英钠片，初始剂量100 mg/次，3次/d，连续3 d后，根据病情逐渐减少剂量，最终维持40 mg/d。治疗组在对照组基础上口服野木瓜片，1.60 g/次，3次/d。两组患者均治疗4周。观察两组患者临床疗效，同时比较治疗前后两组患者VAS、PSQI和LSI-B评分，及血清C反应蛋白（CRP）、血浆P物质（SP）、降钙素基因相关肽（CGRP）、白细胞介素-1β（IL-1β）和5-羟色胺（5-HT）水平。结果 治疗后，对照组临床有效率为80.95%，显著低于治疗组的97.62%，两组比较差异具有统计学意义（P<0.05）。经治疗，两组患者VAS评分和PSQI评分显著降低（P<0.05），而LSI-B评分显著升高（P<0.05），且治疗组患者这些评分明显好于对照组（P<0.05）。经治疗，两组患者血清CRP、SP、CGRP和IL-1β水平明显降低（P<0.05），而5-HT水平明显升高（P<0.05），且治疗组患者的血清学指标水平明显优于对照组（P<0.05）。结论 野木瓜片联合苯妥英钠片治疗三叉神经痛能有效改善患者疼痛症状，可有效改善机体炎症水平，改善患者失眠情况及提高患者生活质量。

Objective To explore the clinical effect of Yemugua Tablets combined with phenytoin in treatment of trigeminal neuralgia. Methods Patients (84 cases) with trigeminal neuralgia in the Second Hospital of Tianjin Medical University from May 2018 to May 2019 were randomly divided into control (42 cases) and treatment (42 cases) groups. Patients in the control group were po irrigation administered with Phenytoin Sodium Tablets, the initial dose was 100 mg/time, three times daily, then gradually reduced dose according to illness after 3 d, and the maintenance dose was 40 mg/d. Patients in the treatment group were po administered with Yemugua Tablets on the basis of the control group, 1.6 g/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacy was evaluated, the scores of VAS, PSQI and LSI-B, and the levels of CRP, SP, CGRP, IL-1β and 5-HT in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 80.95%, which was significantly lower than 97.62% in the treatment group, and there were differences between two groups (P<0.05). After treatment, the scores of VAS and PSQI in two groups were significantly decreased (P<0.05), but the LSI-B scores were significantly increased (P<0.05), and these scores in the treatment group were significantly better than those in the control group (P<0.05). After treatment, the level of CRP, SP, CGRP, IL-1β in two groups was significantly decreased (P<0.05), but the 5-HT level was significantly increased (P<0.05), and these serological indexes in the treatment group were significantly better than those in the control group (P<0.05). Conclusion Yemugua Tablets combined with phenytoin in treatment of trigeminal neuralgia can effectively improve the pain symptoms,, improve insomnia and the quality of life of patients.

R971