目的 研究桂芍镇痫片联合丙戊酸钠缓释片治疗小儿癫痫的临床疗效。方法 选取2017年12月-2019年12月许昌市第二人民医院收治的92例癫痫患儿为研究对象，将所有患者随机分为对照组和治疗组，每组各46例。对照组患儿口服丙戊酸钠缓释片，30 mg/（kg·d），3次/d。治疗组在对照组基础上口服桂芍镇痫片，6片/次，3次/d。两组患儿持续治疗2个月。观察两组的临床疗效，比较两组的临床症状情况、血清炎性因子肿瘤坏死因子-α（TNF-α）、高敏C反应蛋白（hs-CRP）和白细胞介素-6（IL-6）水平以及血清学指标。结果 治疗后，治疗组总有效率95.65%，显著高于对照组的80.43%（P<0.05）。治疗后，两组患儿癫痫发作次数和平均症状控制时间明显降低（P<0.05）；且治疗组降低的较多（P<0.05）。治疗后，两组血清TNF-α、hs-CRP和IL-6水平显著降低（P<0.05）；并且治疗组血清炎性因子水平显著低于对照组（P<0.05）。治疗后，两组血清脑源性神经营养因子（BDNF）和神经元特异性烯醇化酶（NSE）水平显著降低（P<0.05）；并且治疗组血清BDNF和NSE水平显著低于对照组（P<0.05）。结论 桂芍镇痫片联合丙戊酸钠缓释片治疗小儿癫痫具有较好的临床疗效，能够改善临床症状，降低血清因子水平，值得在临床上推广应用。

Objective To study the effect of Guishao Zhenxian Tablets combined with Sodium Valproate Sustained-release Tablets in treatment of epilepsy in children. Methods Children (84 cases) with epilepsy in the Second People's Hospital of Xuchang from December 2017 to December 2019 were randomly divided into control and treatment groups, and each group had 46 cases. Children in the control group were po administered with Sodium Valproate Sustained-release Tablets, 30 mg/(kg·d), three times daily. Children in the treatment group were po administered with Guishao Zhenxian Tablets on the basis of the control group, 6 tablets/time, three times daily. Patients in two groups were treated for 2 months. After treatment, the clinical efficacies were evaluated, and clinical symptom; serological indexes, the serum levels of inflammatory factors TNF-α, hs-CRP, and IL-6 in two groups were compared. Results After treatment, the total effective rate of the treatment group was 95.65%, which was significantly higher than that of the control group (80.43%) (P<0.05). After treatment, the seizure frequency and the average symptom control time of two groups were significantly reduced (P<0.05), and these indexes in the treatment group were much lower than those in the control group (P<0.05). After treatment, the serum levels of TNF-α, hs-CRP and IL-6 in two groups were significantly decreased (P<0.05); and the serum levels of inflammatory factors in the treatment group were significantly lower than those in the control group (P<0.05). After treatment, the serum levels of BDNF and NSE in the two groups were significantly decreased (P<0.05), and the serum levels of BDNF and NSE in the treatment group were significantly lower than those in the control group (P<0.05). Conclusion Guishao Zhenxian Tablets combined with Sodium Valproate Sustained-release Tablets has clinical curative effect in treatment of epilepsy in children, can improve clinical symptoms and reduce serum factor level, which is worthy of clinical application.

R985

河南省科技攻关项目（2018ZY2095）