目的 探讨抗宫炎片联合左氧氟沙星片治疗慢性盆腔炎的临床疗效。方法 选取2017年7月-2018年7月焦作市第二人民医院收治的126例慢性盆腔炎性疾病患者作为研究对象，将所有患者随机分为对照组和治疗组，每组各63例。对照组患者口服左氧氟沙星片，1片/次，1次/d。治疗组在对照组的基础上口服抗宫炎片，3片/次，3次/d。两组患者持续治疗2周。观察两组患者的临床疗效，比较两组的临床症状消退时间、炎症因子水平。结果 治疗后，治疗组的总有效率为95.24%，高于对照组的85.71%，组间差异显著（P<0.05）。治疗后，治疗组患者白带复常时间、盆腔肿块消失时间、下腹坠胀消失时间、炎性渗出消失时间、腹痛缓解时间均明显短于对照组（P<0.05）。治疗后，两组患者肿瘤坏死因子-α（TNF-α）、白细胞介素（IL）-1β、超敏C-反应蛋白（hs-CRP）水平均显著降低，IL-10、IL-4水平明显升高，组内差异显著（P<0.05），治疗后治疗组的各指标改善水平明显优于对照组，组间差异显著（P<0.05）。结论 抗宫炎片联合左氧氟沙星片治疗慢性盆腔炎的疗效确切，能降低患者的临床症状消失时间，抑制炎症，值得临床推广。

Objective To investigate the clinical efficacy of Kanggongyan Tablets combined with Levofloxacin Tablets in treatment of chronic pelvic inflammatory disease. Methods Patients (126 cases) with chronic pelvic inflammatory disease in Jiaozuo Second People's Hospital from July 2017 to July 2018 were randomly divided into control and treatment groups, and each group had 63 cases. Patients in the control group were po administered with Levofloxacin Tablets, 1 tablet/time, once daily. Patients in the treatment group were po administered with Kanggongyan Tablets on the basis of the control group, 3 tablets/time, three times daily. Patients in two groups were treated for 2 weeks. After treatment, the clinical efficacies were evaluated, and clinical symptoms subsided time and the serum levels of inflammatory factors in two groups were compared. Results After treatment, the total effective rate of the treatment group was 95.24%, which was higher than 85.71% of the control group (P<0.05). After treatment, the leucorrhea recovery time, pelvic mass disappearance time, abdominal distention disappeared time, inflammatory exudation time and abdominal pain relief time in the treatment group were significantly shorter than those in the control group (P<0.05). After treatment, the levels of TNF-α, IL-1β, and hs-CRP in the two groups were decreased, but the levels of IL-10 and IL-4 were increased (P<0.05). After treatment, the improvement of these indexes in the treatment group was better than those in the control group (P<0.05). Conclusion Kanggongyan Tablets combined with Levofloxacin Tablets has clinical curative effect in treatment of chronic pelvic inflammatory disease, can reduce the disappearance time of clinical symptoms, and inhibit inflammation, which is worthy of clinical promotion.

R984

河南省医学科技攻关计划联合共建项目（LHGJ20191350）