[关键词]
[摘要]
目的 探讨疏风解毒胶囊联合氨茶碱注射液治疗慢性支气管炎急性发作的临床疗效。方法 选择2018年1月-2020年1月天津市宁河区医院收治的88例慢性支气管炎急性发作患者,随机分为对照组(44例)和治疗组(44例)。对照组静脉滴注氨茶碱注射液,0.25 g加到15%葡萄糖溶液250 mL中,3次/d。治疗组在对照组治疗的基础上口服疏风解毒胶囊,4粒/次,3次/d。两组均连续治疗1周。观察两组的临床疗效,比较两组患者治疗前后第一秒用力呼气量(FEV1)、用力肺活量(FVC)、最大呼气流速(PEF)、血氧分压(pO2)、二氧化碳分压(pCO2)、肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)及白细胞介素-8(IL-8)水平的变化情况。结果 治疗组的临床总有效率为95.45%,对照组是77.27%,两组总有效率比较差异有统计学意义(P<0.05)。两组治疗后FEV1、FVC及PEF均明显比治疗前高(P<0.05),同时治疗组治疗后FEV1、FVC及PEF均明显比对照组高(P<0.05)。两组治疗后pO2均明显高于治疗前,pCO2均明显低于治疗前(P<0.05),同时治疗组治疗后pO2明显高于对照组,pCO2明显低于对照组(P<0.05)。两组治疗后血清TNF-α、CRP及IL-8水平均明显比治疗前低(P<0.05),同时治疗组治疗后血清TNF-α、CRP及IL-8水平均明显比对照组低(P<0.05)。两组治疗期间均无严重的不良反应发生。结论 疏风解毒胶囊联合氨茶碱注射液治疗慢性支气管炎急性发作的临床疗效显著,能够明显提升肺功能,改善血气指标,降低血清炎性因子水平,具有一定的临床推广应用价值。
[Key word]
[Abstract]
Objective To explore the clinical efficacy of Shufeng Jiedu Capsules combined with Aminophylline Injection in treatment of acute exacerbation of chronic bronchitis. Methods 88 Patients with acute exacerbation of chronic bronchitis admitted to Tianjin Ninghe District Hospital from January 2018 to January 2020 in Tianjin Ninghe District Hospital were randomly divided into control group (44 cases) and treatment group (44 cases). The control group was iv administered with Aminophylline Injection, 0.25 g added to 15% Glucose Solution250 mL, three times daily. The treatment group was po administered with Shufeng Jiedu Capsules, 4 grains/time, three times daily. All patients were treated for 1 week. The clinical efficacy in two groups were observed, and the changes of FEV1, FVC, PEF, pO2, pCO2, TNF-α, CRP, and IL-8 before and after in two groups were compared. Results The total effective rate was 95.45% in the treatment group and 77.27% in the control group, and there were differences between two groups (P<0.05). After treatment, FEV1, FVC and PEF in both groups were significantly higher than those before treatment (P<0.05), and FEV1, FVC and PEF in the treatment group were significantly higher than those in the control group (P<0.05). After treatment, pO2 was significantly higher than that before treatment, but pCO2 was significantly lower than that before treatment (P<0.05). After treatment, pO2 in the treatment group was higher than that in the control group, but pCO2 was significantly lower than the control group, and there were differences between two groups (P<0.05). No serious adverse reactions occurred during the treatment in both groups. Conclusions Shufeng Jiedu Capsules combined with Aminophylline Injection has a significant clinical effect in treatment of acute exacerbation of chronic bronchitis, and can significantly improve lung function, improve blood gas index, and reduce the level of serum inflammatory factors, which has a certain clinical application value.
[中图分类号]
R974
[基金项目]
天津市自然科学基金项目(16JCYBJC24185)