目的 研究牙痛宁滴丸联合米诺环素软膏治疗慢性牙周炎的临床疗效。方法 选取2017年10月—2019年10月在淅川县中医院治疗的60例慢性牙周炎患者（110颗患牙），将所有患者随机分为对照组和治疗组，每组各30例55颗患牙。对照组患者给予盐酸米诺环素软膏，1次/周，连续用4次。治疗组在对照组基础上口服牙痛宁滴丸，10粒/次，3次/d。两组患者治疗4周。观察两组患者临床疗效，对比两组患者治疗前后牙周指标、口腔保健自我效能量表（SESS）评分、口腔健康影响程度量表（OHIP-14）评分和视觉模拟评分法（VAS）评分、龈沟液炎性因子水平变化。结果 治疗后，治疗组总有效率（96.36%）显著高于对照组（83.64%）（P<0.05）。治疗后，两组患者SESS评分显著升高，OHIP-14和VAS评分均显著降低（P<0.05）；且治疗组SESS评分高于对照组，OHIP-14和VAS评分均低于对照组（P<0.05）。治疗后，两组患者菌斑指数（PLI）、牙周袋深度（PD）、龈沟出血指数（SBI）、牙周附着水平（AL）均显著降低（P<0.05），且治疗组牙周指标降低程度较大（P<0.05）。治疗后，两组患者龈沟液肿瘤坏死因子-α（TNF-α）和白细胞介素-1β（IL-1β）水平均显著降低（P<0.05），且治疗组龈沟液炎性因子水平降低程度较大（P<0.05）。结论 牙痛宁滴丸联合米诺环素软膏治疗慢性牙周炎具有较好的治疗效果，能改善牙周指标和临床症状，降低龈沟液炎性因子水平，安全性较高，值得在临床上推广应用。

Objective To study the effect of Yatongning Dropping Pills combined with Minocycline Hydrochloride Ointment in treatment of chronic periodontitis. Methods Patients (60 cases, 110 teeth) with chronic periodontitis in Xichuan County Hospital of Traditional Chinese Medicine from October 2017 to October 2019 were randomly divided into control and treatment groups, and each group had 42 cases (55 teeth). Patients in the control group were given Minocycline Hydrochloride Ointment, once weekly, continuously administered 4 times. Patients in the treatment group were po administered with Yatongning Dropping Pills on the basis of the control group, 10 grains/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacies were evaluated, and periodontal indexes, SESS scores, OHIP-14 scores, VAS scores, and the levels of inflammatory factors in gingival crevicular fluid before and after treatment in two groups were compared. Results After treatment, the total effective rate of the treatment group (96.36%) was significantly higher than that of the control group (83.64%) (P<0.05). After treatment, the SESS scores of two groups were significantly increased, but the OHIP-14 scores and VAS scores of two groups were significantly decreased (P<0.05). And the SESS score in the treatment group was significantly higher than that in the control group, but the OHIP-14 score and VAS score in the control group were significantly lower than those in the control group (P<0.05). After treatment, the PLI, PD, SBI, and AL of the two groups were significantly decreased (P<0.05), and the periodontal indexes of the treatment group were significantly lower than those of the control group (P<0.05). After treatment, the levels of TNF-α and IL-1β in gingival crevicular fluid of two groups were significantly decreased (P<0.05), and the levels of inflammatory factors in gingival crevicular fluid of the treatment group were significantly lower than those of the control group (P<0.05). Conclusion Yatongning Dropping Pills combined with Minocycline Hydrochloride Ointment has clinical curative effect in treatment of chronic periodontitis, can improve periodontal indexes and clinical symptoms, reduce the levels of inflammatory factors in gingival crevicular fluid, with high safety, which is worthy of clinical application.

R988.2