目的 探讨肠炎宁糖浆联合头孢克肟干混悬剂治疗小儿急性肠胃炎的临床疗效。方法 选取2017年7月—2019年7月在宝鸡市妇幼保健院治疗的急性肠胃炎患儿82例，根据用药的差别分为对照组（41例）和治疗组（41例）。对照组口服头孢克肟干混悬剂，1.5～3 mg/kg，2次/d；治疗组在对照组基础上口服肠炎宁糖浆，10 mL/次，3次/d。两组患儿均经7 d。观察两组患者临床疗效，同时比较治疗前后两组患者临床症状改善时间，以及血清超敏C反应蛋白（hs-CRP）、白细胞介素-6（IL-6）和降钙素（PCT）水平。结果 治疗后，对照组临床有效率为80.49%，显著低于治疗组的97.56%，两组比较差异具有统计学意义（P<0.05）。治疗后，治疗组患儿腹痛缓解时间、发热缓解时间、呕吐缓解时间、腹泻缓解时间均明显短于对照组（P<0.05）。治疗后，两组患者血清hs-CRP、IL-6、PCT水平均明显下降（P<0.05），且治疗组患者明显低于对照组（P<0.05）。结论 肠炎宁糖浆联合头孢克肟干混悬剂治疗小儿急性肠胃炎可有效改善患儿临床症状，降低机体炎症反应，具有一定的临床推广应用价值。

Objective To investigate the clinical efficacy of Changyanning Syrup combined with cefixime in treatment of acute gastroenteritis in children. Methods Children (82 cases) with acute gastroenteritis in Baoji Maternal and Child Health Hospital from July 2017 to July 2019 were divided into control (41 cases) and treatment (41 cases) groups based on different treatments. Children in the control group were po administered with Cefixime for suspension, 1.5 — 3 mg/kg, twice daily. Children in the treatment group were po administered with Changyanning Syrup on the basis of the control group, 10 mL/time, three times daily. Children in two groups were treated for 7 d. After treatment, the clinical efficacy was evaluated, and the improvement time of clinical symptoms, the serum level of hs-CRP, IL-6 and PCT in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 80.49%, which was significantly lower than 97.56% in the treatment group, and there were differences between two groups (P<0.05). After treatment, the remission time of abdominal pain, fever, vomiting, diarrhea in the treatment group was significantly shorter than that in the control group (P<0.05). After treatment, the serum levels of hs-CRP, IL-6, and PCT in two groups were significantly decreased (P<0.05), and which in the treatment group were significantly lower than those in the control group (P<0.05). Conclusion Changyanning Syrup combined with cefixime in treatment of acute gastroenteritis in children can effectively improve the clinical symptoms and reduce the inflammatory response, which has a certain clinical application value.

R975