长期以来，慢性阻塞性肺疾病（COPD）困扰着很多患者，由于其多样性的临床分型、复杂的作用机制，COPD目前尚缺少明确的生物标志物用于早期诊断、干预和治疗。对临床分型和生物标志物的准确分析能够有效提示疾病的发展进程，指导临床用药，进行精准治疗。对近年来报道的慢性阻塞性肺病的临床分型和生物标志物进行综述，期望为基础研究、临床诊断治疗提供参考依据和指导作用。

Chronic obstructive pulmonary disease (COPD) plagues many patients for a long time, due to its diverse clinical classification and complex mechanism. There are still few clear biomarkers for early diagnosis, intervention and treatment of chronic obstructive pulmonary disease. Accurate analysis of clinical typing and biomarkers can effectively prompt the development process of the disease, guide clinical medication, and perform precise treatment. The types and biomarkers of chronic obstructive pulmonary disease reported in recent years are reviewed in this article, hoping to provide reference and guidance for basic research, clinical diagnosis, and treatment.

R974

天津市卫健委中医中西医综合科研项目（2019126）