目的 研究牙痛一粒丸联合甲硝唑含片治疗牙龈炎的临床疗效。方法 选取2018年9月—2019年9月在辽宁省健康产业集团抚矿总医院治疗的120例牙龈炎患者，所有患者随机分为对照组和治疗组，每组各60例。对照组患者给予甲硝唑含片，一次连续含3～4片，3～4次/d；治疗组在对照组基础上给予牙痛一粒丸，1丸/次，1次/d。两组患者持续治疗14 d。观察两组患者治疗后临床疗效，比较两组VAS评分、口腔健康影响程度量表（OHIP-14）评分、菌斑指数、牙龈指数、牙周袋深度以及龈沟液炎症因子水平。结果 治疗后，治疗组总有效率（96.67%）显著高于对照组（78.33%），差异有统计学意义（P<0.05）。治疗后，两组VAS评分和OHIP-14评分明显下降（P<0.05），且治疗组VAS评分和OHIP-14评分降低较多（P<0.05）。治疗后，两组菌斑指数、牙龈指数、牙周袋深度均明显降低（P<0.05），且治疗组菌斑指数、牙龈指数、牙周袋深度均明显低于对照组（P<0.05）。治疗后，两组龈沟液肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）、白细胞介素-8（IL-8）水平显著降低（P<0.05）；并且治疗组龈沟液炎性因子水平降低较多（P<0.05）。结论 牙痛一粒丸联合甲硝唑含片治疗牙龈炎具有较好的临床疗效，能够改善患者口腔健康，降低龈沟液炎性因子水平，值得在临床上推广应用。

Objective To study the clinical effect of Yatong Yili Pills combined with Metronidazole Buccal Tablets in treatment of gingivitis. Methods Patients (120 cases) with gingivitis in Fukuang General Hospital of Liaoning Health Industry Group from September 2018 to September 2019 were randomly divided into control and treatment groups, and each group had 60 cases. Patients in the control group were given Metronidazole Buccal Tablets, 3-4 tablets/time, three to four times daily. Patients in the treatment group were given Yatong Yili Pills on the basis of the control group, 1 pill/time, once daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacies were evaluated, and VAS score, OHIP-14 score, plaque index, gingival index, periodontal pocket depth, and the levels of inflammatory factors of gingival crevicular fluid in two groups were compared. Results After treatment, the total effective rate of the treatment group (96.67%) was significantly higher than that of the control group (78.33%) (P<0.05). After treatment, VAS scores and OHIP-14 scores in two groups were significantly decreased (P<0.05). And the VAS score and OHIP-14 score in the treatment group were significantly lower than those in the control group (P<0.05). After treatment, plaque index, gingival index and periodontal pocket depth in two groups were significantly decreased (P<0.05). And the plaque index, gingival index, and periodontal pocket depth in the treatment group were significantly lower than those in the control group (P<0.05). After treatment, the levels of IL-6, IL-8, and TNF-α in gingival crevicular fluid of the two groups were significantly reduced (P<0.05). And the observational indexes in the treatment group were significantly lower than those of the control group (P<0.05). Conclusion Yatong Yili Pills combined with Metronidazole Buccal Tablets has a good clinical effect in the treatment of gingivitis, can improve the oral health of patients and reduce the level of inflammatory factors in gingival crevicular fluid, which is worthy of clinical application.

R988.2