目的 研究丁硼乳膏联合奥硝唑片治疗慢性牙周炎的临床疗效。方法 选取2018年1月—2019年10月在淅川县中医院治疗的80例（140颗患牙）慢性牙周炎患者，将所有患者随机分为对照组和治疗组，每组各40例70颗患牙。对照组患者口服奥硝唑片，2片/次，2次/d。治疗组在对照组基础上在饭后和睡前用丁硼乳膏1 g刷牙，然后将丁硼乳膏1 g挤在患处轻轻撩擦5 min左右，然后漱口。两组患者持续治疗2周。观察两组的临床疗效，比较两组VAS评分、菌斑指数、牙龈指数、牙周附着水平、探针深度；并检测两组炎性因子白细胞介素-6（IL-6）、白细胞介素-8（IL-8）、肿瘤坏死因子-α（TNF-α）水平。结果 治疗后，治疗组总有效率95.00%明显高于对照组的82.50%（P<0.05）。治疗后，两组VAS评分显著降低（P<0.05），且治疗组VAS评分降低较多（P<0.05）。治疗后，两组患者牙龈指数、菌斑指数、探针深度和牙周附着水平明显降低（P<0.05）；且治疗组牙周指标降低较多（P<0.05）。治疗后，两组患者IL-6、IL-8、TNF-α水平均显著降低（P<0.05）；并且治疗组炎性因子水平降低较多（P<0.05）。结论 丁硼乳膏联合奥硝唑片治疗慢性牙周炎具有较好的治疗效果，能够降低疼痛度，改善牙周指标，降低炎性因子水平，值得在临床上推广应用。

Objective To study the curative effect of Dingpeng Cream combined with Ornidazole Tablets in treatment of chronic periodontitis. Methods Patients (80 cases, 140 teeth) with chronic periodontitis in Xichuan Hospital of Traditional Chinese Medicine from January 2018 to October 2019 were randomly divided into control and treatment groups, and each group had 40 cases (70 teeth). Patients in the control group were po administered with Ornidazole Tablets, 2 tablets/time, twice daily. Patients in the treatment group were given Dingpeng Cream on the basis of the control group, brushed teeth with 1g, then brushed the affected area with 1g for about 5 min, then rinsed mouth. Patients in two groups were treated for 2 weeks. After treatment, the clinical efficacies were evaluated, and VAS scores, plaque indexes, gingival indexes, periodontal attachment level, probe depth, and the levels of IL-6, IL-8, and TNF-α in two groups were compared. Results After treatment, the total effective rate of the treatment group (95.00%) was higher than that of the control group (82.50%) (P<0.05). After treatment, the VAS scores of the two groups were significantly decreased (P<0.05), and the VAS score in the treatment group was lower than that in the control group (P<0.05). After treatment, the gingival index, plaque index, probe depth, and periodontal attachment level in the two groups were significantly decreased (P<0.05), and the periodontal indexes in the treatment group was lower than that of the control group (P<0.05). After treatment, the levels of IL-6, IL-8, and TNF-α in the two groups were significantly decreased (P<0.05), and the inflammatory factor indexes in the treatment group was lower than that of the control group (P<0.05). Conclusion Dingpeng Cream combined with Ornidazole Tablets has clinical curative effect in treatment of chronic periodontitis, can reduce the degree of pain, improve the periodontal index and reduce the level of inflammatory factors, which is worthy of clinical application.

R988.2