目的 观察小儿肺咳颗粒联合环酯红霉素治疗急性小儿支气管炎的临床疗效。方法 选择2018年6月—2019年6月在彭州市妇幼保健计划生育中心就诊的急性支气管炎患儿216例，随机分为对照组和治疗组，每组各108例。对照组口服环酯红霉素干混悬剂，10～15 mg/kg，1次/12 h；治疗组在对照组基础上口服小儿肺咳颗粒，1岁以下患儿2 g/次、1～4岁患儿3 g/次、5～8岁6 g/次，3次/d。两组患儿均治疗7 d。观察两组患者临床疗效，同时比较治疗前后两组患者临床症状改善情况，及超敏C反应蛋白（hs-CRP）、白细胞介素-10（IL-10）和IL-13水平。结果 治疗后，对照组和治疗组临床有效率分别为75.93%和93.52%，两组比较差异具有统计学意义（P<0.05）。治疗后，治疗组患者体温恢复正常时间、咳嗽消失时间、肺部喘鸣音消失时间均较对照组明显缩短（P<0.05）。治疗后，两组患者hs-CRP、IL-10和IL-13水平均明显降低（P<0.05），且治疗组患者的炎症指标水平显著低于对照组（P<0.05）。结论 小儿肺咳颗粒联合环酯红霉素治疗急性小儿支气管炎能够快速缓解症状，改善炎症指标，具有一定的临床推广应用价值。

Objective To observe the clinical efficacy of Xiaoer Feike Granules combined with erythromycin cyclocarbonate in treatment of acute bronchitis in children. Methods Children (216 cases) with acute bronchitis in Maternity Service Center of Pengzhou Maternal and Child Health Care Hospital from June 2018 to June 2019 were randomly divided into control and treatment groups, and each group had 108 cases. Children in the control group were po administered with Erythromycin Cyclocarbonate for Suspension, 10-15 mg/kg, once every 12 h. Children in the treatment group were po administered with Xiaoer Feike Granules on the basis of the control group, 2 g/time for children under 1 year old, 3 g/time for children under 1-4 years old, 6 g/time for children under 5-8 years old, three times daily. Children in two groups were treated for 7 d. After treatment, the clinical efficacy was evaluated, and the improvement of clinical symptoms, the indicators of hs-CRP, IL-10 and IL-13 in two groups before and after treatment were compared. Results After treatment, the clinical efficacy and in the control and treatment groups was 75.93% and 93.52% respectively, and there were differences between two groups (P<0.05). After treatment, the time of temperature returned to normal, cough disappearing and lung wheezing disappearing in the treatment group was significantly shorter than that in the control group (P<0.05). After treatment, the level of hs-CRP, IL-10 and IL-13 in two groups was significantly decreased (P<0.05), and these inflammation indexes in the treatment group were significantly lower than those in the control group (P<0.05). Conclusion Xiaoer Feike Granules combined with erythromycin cyclocarbonate in treatment of acute bronchitis in children can quickly alleviate symptoms and improve inflammatory indicators, which has a certain clinical application value.

R974