目的 分析舒冠颗粒联合氯吡格雷治疗冠心病心绞痛的临床效果。方法 选择2017年2月—2019年3月在海南省干部疗养院治疗的冠心病心绞痛患者98例，随机分成对照组（48例）和治疗组（50例）。对照组患者口服硫酸氢氯吡格雷片，1片/次，1次/d。治疗组在对照组的用药基础上口服舒冠颗粒，1袋/次，3次/d。两组患者均治疗1个月。观察两组患者临床疗效，同时比较治疗前后两组患者心绞痛发作情况，以及左心室射血分数（LVEF）、左心室舒张末期内径（LVEDD）、左心室收缩末期内径（LVESD）、血清五聚素3（PTX3）、白介素-6（IL-6）和超敏C反应蛋白（hs-CRP）水平。结果 治疗后，对照组和治疗组临床有效率分别为70.83%和92.00%，两组比较差异具有统计学意义（P<0.05）。治疗后，两组发作频率、发作时间均明显改善（P<0.05），且治疗组明显优于对照组（P<0.05）。治疗后，两组LVEF水平明显升高，而LVEDD和LVESD水平均明显降低（P<0.05）；且治疗组LVEF、LVEDD和LVESD改善效果明显优于对照组（P<0.05）。治疗后，两组PTX3、IL-6和hs-CRP水平均明显降低（P<0.05），且治疗组患者明显低于对照组（P<0.05）。结论 舒冠颗粒联合氯吡格雷治疗冠心病心绞痛临床效果显著，可明显缓解症状，改善心功能，抑制炎症反应。

Objective To analyze the clinical effect of Shuguan Granules combined with clopidogrel in treatment of angina pectoris of coronary heart disease. Methods Patients (98 cases) with angina pectoris of coronary heart disease in Cadre sanatorium of Hainan & Geriatric hospital of Hainan (CSH) from February 2017 to March 2019 were randomly divided into control (48 cases) and treatment (50 cases) groups. Patients in the control group were po administered with Clopidogrel Hydrogen Sulphate Tablets, 1 tablet/time, once daily. Patients in the treatment group were po administered with Shuguan Granules on the basis of the control group, 1 bag/time, three times daily. Patients in two groups were treated for 1 month. After treatment, the clinical efficacy was evaluated, and the attack of angina pectoris, the level of LVEF, LVEDD, LVESD, PTX3, IL-6 and hs-CRP in two groups before and after treatment were compared. Results After treatment, the clinical efficacy and in the control and treatment groups was 70.83% and 92.00% respectively, and there were differences between two groups (P<0.05). After treatment, the frequency and duration of angina pectoris in two groups was significantly improved (P<0.05), and which in the treatment group was significantly better than that in the control group (P<0.05). After treatment, the LVEF level in two groups was significantly increased (P<0.05), but the LVEDD and LVESD level was significantly decreased (P<0.05), and the LVEF, LVEDD and LVESD in the treatment group were significantly better than those in the control group (P<0.05). After treatment, the PTX3, IL-6, and hs-CRP level in two groups were significantly decreased (P<0.05), and which in the treatment group were significantly lower than that in the control group (P<0.05). Conclusion Shuguan Granules combined with clopidogrel in treatment of angina pectoris of coronary heart disease has significant clinical effect, can obviously relieve the clinical symptoms, effectively improve cardiac function, and inhibit inflammatory reactions.

R972