目的 探讨口炎清颗粒联合硫酸羟氯喹片治疗糜烂型口腔扁平苔藓的临床疗效。方法 选取2018年2月—2019年12月天津市口腔医院和天津医科大学口腔医院收治的82例口腔扁平苔藓患者作为研究对象，将所有患者按照随机数字表法分为对照组和治疗组，每组各41例。对照组口服硫酸羟氯喹片，2片/次，2次/d。治疗组在对照组基础上温水冲服口炎清颗粒，20 g/次，2次/d。两组患者连续治疗1个月。比较两组的总有效率，使用视觉模拟评分法（VAS）评估患者的主观疼痛程度，对比两组患者治疗前后病损面积的大小，检测两组患者治疗前后氧化应激指标超氧化物歧化酶（SOD）、脂质过氧化物（LPO）、丙二醛（MDA）水平。结果 治疗后，治疗组的总有效率95.12%比对照组的80.49%高，差异有统计学意义（P<0.05）。治疗后，两组的VAS评分、病损面积明显降低（P<0.05）；治疗后治疗组的VAS评分、病损面积比对照组低（P<0.05）。治疗后，两组的SOD水平明显升高，LPO、MDA水平明显降低（P<0.05）；治疗后治疗组的SOD比对照组高，LPO、MDA比对照组低（P<0.05）。结论 口炎清颗粒联合硫酸羟氯喹片治疗糜烂型口腔扁平苔藓疗效较好，可减轻疼痛程度，缩小病损面积，减轻氧化应激反应，具有良好的临床研究价值。

Objective To explore the clinical effect of Kouyanqing Granules combined with Hydroxychloroquine Sulfate Tablets in treatment of erosive oral lichen planus. Methods Patients (82 cases) with erosive oral lichen planus in Tianjin Stomatology Hospital and Tianjin Medical University Dental hospital from February 2018 to December 2019 were randomly divided into control and treatment groups, and each group had 41 cases. Patients in the control group were po administered with Hydroxychloroquine Sulfate Tablets, 2 tablets/time, twice daily. Patients in the treatment group were po administered with Kouyanqing Granules on the basis of the control group, 20 g/time, twice daily. Patients in two groups were treated for 1 month. After treatment, the clinical efficacies were evaluated, and visual analogue scale (VAS) was used to evaluate the degree of subjective pain. Before and after treatment, the size of lesion area was compared between two groups, and the levels of superoxide dismutase (SOD), lipid peroxide (LPO), and malondialdehyde (MDA) were measured. Results After treatment, the total effective rate of the treatment group was (95.12%) higher than that of the control group (80.49%) (P<0.05). After treatment, the VAS score and lesion area in two groups were significantly reduced (P<0.05). After treatment, the VAS score and lesion area in the treatment group were lower than that in the control group (P<0.05). After treatment, the levels of SOD in two groups were significantly increased, but the levels of LPO and MDA in two groups were significantly decreased (P<0.05). After treatment, the level of SOD in the treatment group was higher than that in the control group, but the levels of LPO and MDA in the treatment group were lower than that in the control group, with a statistically significant difference (P<0.05). Conclusion Kouyanqing Granules combined with Hydroxychloroquine Sulfate Tablets has clinical curative effect in treatment of erosive oral lichen planus, can reduce pain and lesion area, and relieve oxidative stress, which has good clinical research value.

R988.2

天津市口腔医院博硕重点青年项目（2019 BSQN05）