[关键词]
[摘要]
目的 分析安儿宁颗粒联合乳糖酸红霉素治疗小儿上呼吸道感染的临床效果。方法 选取2017年3月—2019年2月郑州大学附属儿童医院治疗的上呼吸道感染患儿137例,随机分成对照组(n=68)和治疗组(n=69)。对照组静脉滴注注射用乳糖酸红霉素,25 mg/kg溶于250 mL生理盐水,1次/d。治疗组在对照组治疗基础上口服安儿宁颗粒,1~5岁患儿3 g/次,5岁以上6 g/次,3次/d。两组患儿均治疗7 d。观察两组的临床疗效,比较两组临床症状消失时间、血清炎性因子的变化情况。结果 治疗后,对照组和治疗组的总有效率分别是72.06%、94.20%,两组比较差异有统计学意义(P<0.05)。治疗组咳嗽、咽痛、发热和流鼻涕等临床症状消失时间明显短于对照组,两组比较差异有统计学意义(P<0.05)。与治疗前相比,治疗后两组患者肿瘤坏死因子-α(TNF-α)、白介素-1β(IL-1β)、白介素-10(IL-10)指标均明显降低(P<0.05);且治疗后治疗组患者TNF-α、IL-1β和IL-10指标明显低于对照组,两组比较差异具有显著统计学意义(P<0.05)。结论 安儿宁颗粒联合乳糖酸红霉素治疗小儿上呼吸道感染具有较好的临床疗效,可快速缓解患儿咳嗽、咽痛、发热和流鼻涕等临床症状,改善机体炎症反应水平,具有较好的临床疗效。
[Key word]
[Abstract]
Objective To analyze the clinical effect of Anerning Granules combined with erythromycin lactobionate in treatment of upper respiratory tract infection in children. Methods 137 Children with upper respiratory tract infection treated in Children's Hospital of Zhengzhou University from March 2017 to February 2019 were selected and randomly divided into control group (n=68) and treatment group (n=69). The control group was iv administered with Erythromycin Lactobionate for injection, 25 mg/kg was dissolved in normal saline 250 mL, once daily. The treatment group was po administered with Anerning Granules on the basis of the control group, 3 g/time for children aged 1 to 5 years old, 6 g/time for children over 5 years old, 3 times/daily. All children were treated for 7 days. The clinical efficacy in two groups was observed, and the disappearance time of clinical symptoms and the changes of serum inflammatory factors in the two groups were compared. Results The total effective rates in the control and treatment group were 72.06%, 94.20%, respectively, and there were differences between two groups (P<0.05). The disappearance time of clinical symptoms such as cough, sore throat, fever and runny nose in the treatment group was significantly shorter than that in the control group, and there were differences between two groups (P<0.05). The levels of TNF-α, IL-1β, and IL-10 were significantly reduced in both groups after treatment compared with before treatment. After treatment, the indicators of TNF-α, IL-1β, and IL-10 in the treatment group were significantly lower than those in the control group, and the differences between the two groups were statistically significant (P<0.05). Conclusion Anerning Granules combined with erythromycin lactobionate has good clinical effect in treatment of upper respiratory tract infection in children, and can quickly relieve the clinical symptoms of cough, sore throat, fever and runny nose, and improve the level of inflammatory response, which has a certain clinical application value.
[中图分类号]
R974
[基金项目]
河南省2019年科技发展计划项目(192102310073)