[关键词]
[摘要]
目的 探讨雪梨止咳糖浆联合布地奈德福莫特罗吸入剂治疗儿童咳嗽变异性哮喘的临床疗效。方法 选取2018年6月—2019年11月在天津市宁河区医院治疗的110例咳嗽变异性哮喘患儿作为研究对象,按照随机数字表法将全部患儿分为对照组和治疗组,每组各55例。对照组雾化吸入布地奈德福莫特罗吸入剂,1吸/次,2次/d。治疗组在对照组基础上口服雪梨止咳糖浆,5 mL/次,3次/d。两组患儿连续治疗4周。观察两组的控制率,比较两组的咳嗽消失时间、气喘消失时间、哮鸣音消失时间、日间咳嗽评分、夜间咳嗽评分、肺功能和诱导痰白细胞介素-6(IL-6)、组织中P物质(SP)、嗜酸性粒细胞阳离子蛋白(ECP)水平。结果 治疗后,治疗组的控制率(92.73%)明显高于对照组(78.18%),差异有统计学意义(P<0.05)。治疗后,治疗组的咳嗽消失时间、气喘消失时间、哮鸣音消失时间比对照组短,差异有统计学意义(P<0.05)。治疗后,两组的日间咳嗽评分、夜间咳嗽评分明显低于治疗前(P<0.05);且治疗组的日间咳嗽评分、夜间咳嗽评分比对照组低(P<0.05)。治疗后,两组患者第一秒用力呼气容积(FEV1)、FEV1/用力肺活量(FVC)明显升高(P<0.05),且治疗组FEV1、FEV1/FVC较对照组升高的更明显(P<0.05)。治疗后,两组患者诱导痰的IL-6、SP、ECP明显降低(P<0.05),且治疗组IL-6、SP、ECP较对照组降低的更明显(P<0.05)。结论 雪梨止咳糖浆联合布地奈德福莫特罗吸入剂可提高小儿咳嗽变异性哮喘的疗效,减轻患儿的咳嗽症状,改善肺功能,减轻炎症反应,具有一定的临床研究价值。
[Key word]
[Abstract]
Objective To explore the clinical effect of Xueli Zhike Syrup combined with Budesonide and Formoterol Fumarate Powder for inhalation in treatment of cough variant asthma in children. Methods Children (110 cases) with cough variant asthma in Tianjin Ninghe District Hospital from June 2018 to November 2019 were randomly divided into control and treatment groups, and each group had 55 cases. Children in the control group were atomization inhalation administered with Budesonide and Formoterol Fumarate Powder for inhalation, 1 suction/time, twice daily. Patients in the treatment group were po administered with Xueli Zhike Syrup on the basis of the control group, 5 mL/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the control rates were evaluated, and the disappearance time of cough, asthma and wheezing, the daytime cough score, the nighttime cough score, the pulmonary function, and the levels of IL-6, SP and ECP in two groups were compared. Results After treatment, the control rate in the treatment group (92.73%) was significantly higher than that in the control group (78.18%) (P<0.05). After treatment, the disappearance time of cough, asthma and wheezing in the treatment group was shorter than that in the control group (P<0.05). After treatment, the daytime cough score and nocturnal cough score in the two groups were significantly lower than those before treatment (P<0.05), and the daytime cough score and night cough score in the treatment group were lower than those in the control group (P<0.05). After treatment, the FEV1 and FEV1/FVC in the two groups were significantly increased (P<0.05), and the FEV1 and FEV1/FVC in the treatment group were higher than those in the control group, with a statistically significant difference (P<0.05). After treatment, the levels of IL-6, SP, and ECP in induced sputum in the two groups were significantly decreased (P<0.05), and the levels of IL-6, SP, and ECP in the treatment group were significantly lower than those in the control group (P<0.05). Conclusion Xueli Zhike Syrup combined with Budesonide and Formoterol Fumarate Powder for inhalation can improve the curative effect of cough variant asthma in children, reduce cough symptoms, improve lung function and reduce inflammatory reaction, which has certain clinical research value.
[中图分类号]
R974
[基金项目]
秦皇岛市科学技术研究与发展计划项目(201602A183)