目的 调查头孢西丁致过敏性休克的报道情况，为临床安全用药及开展药学监护提供依据。方法 检索中文科技期刊全文数据库（维普）、中国学术期刊（网络版）、万方数字化期刊全文库，以"头孢西丁"和"过敏性休克"为标题检索词，对1999年1月-2019年10月关于头孢西丁致过敏性休克的报道进行统计、分析。结果 共检索到17篇文献，结合本院1例，共计22例病例。包括男性9例，女性13例，平均年龄41岁；预防性用药6例，治疗性用药16例。消化系统疾病、呼吸系统疾病构成比分别为45.5%、31.8%。静脉滴注21例，静脉推注1例；在治疗性用药中有6例联合用药，其余均为单独用药。过敏性休克发生时间小于30 min的有19例，大于30 min有3例。结论 医疗机构对头孢西丁所致过敏性休克必须引起重视，加强临床合理用药，用药期间积极开展药学监护。

Objective To investigate the occurrence of anaphylactic shock induced by cefoxitin so as to provide a reference for safe medication and pharmaceutical care. Methods Literatures about anaphylactic shock induced by cefoxitin were collected from Chinese Science and Technology Journal Full-text Database (VIP), Chinese Academic Journal (online), and Wangfang Database from 1999 to 2019, and the data was analyzed statistically. Results A total of 17 literatures involving 22 patients were collected with 9 men and 13 women. The average age was 41 years old. Diseases of digestive system and respiratory system accounted for 45.5% and 31.8%. Cefoxitin was used to preventive infection in 6 patients while the rest 16 were therapeutic infection. 21 Patients were take medication by intravenous drips. Cefoxitin was combined with the other drugs to prevention Infection for 6 cases, and the others were used alone. Anaphylactic shock was happened less than 30 minutes for 19 cases and more than 30 minutes for 3 cases. Conclusion The medical institutions should pay attention to the anaphylactic shock caused by cefoxitin, and the clinical rational use of drugs should be strengthened, and pharmaceutical care should be actively carried out.

R978.1

攀枝花市级指导性科技计划项目（2019ZD-S-41）