目的 探讨小金片联合亮丙瑞林治疗子宫内膜异位症的临床效果。方法 选取2016年1月-2018年6月北京怀柔医院收治的子宫内膜异位症患者90例，随机分成对照组（45例）和治疗组（45例）。对照组皮下注射注射用醋酸亮丙瑞林微球，3.75 mg/次，1次/4周，共治疗3次，初次给药从月经周期的第3天开始。治疗组在对照组基础上口服小金片，2片/次，2次/d。两组患者连续治疗3个月。观察两组患者临床疗效，同时比较治疗前后两组患者主要症状体征改善情况，及促卵泡刺激素（FSH）、促黄体生成素（LH）、雌二醇（E2）、全血低切黏度（LBV）、红细胞聚集指数（EAI）、红细胞比容（HCT）、肿瘤坏死因子-α（TNF-α）、单核细胞趋化蛋白-1（MCP-1）和糖蛋白抗原125（CA125）水平。结果 治疗后，对照组和治疗组临床有效率分别为82.2%和95.6%，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者痛经、盆腔痛、性交痛等VAS评分均显著降低（P<0.05），盆腔包块直径、子宫体积则均显著缩小（P<0.05），且治疗组以上主要症状体征的改善效果均显著优于对照组（P<0.05）。治疗后，两组血清FSH、LH、E2水平均显著降低（P<0.05），且治疗组比对照组下降更显著（P<0.05）。治疗后，治疗组LBV、EAI、HCT值均显著低于对照组（P<0.05）。治疗后，两组患者血清TNF-α、MCP-1及CA125浓度均显著下降（P<0.05）；且治疗组较同期对照组下降更明显（P<0.05）。结论 小金片联合亮丙瑞林治疗子宫内膜异位症有助于促进患者相关症状体征的缓解，调节生殖内分泌功能，改善机体淤血及炎症状态，整体疗效显著，安全可靠。

Objective To investigate the clinical effect of Xiaojin Tablets combined with leuprorelin in treatment of endometriosis. Methods Patients (90 cases) with endometriosis in Beijing Huairou Hospital from January 2016 to June 2018 were randomly divided into control (45 cases) and treatment (45 cases) groups. Patients in the control group were subcutaneous injection administered with Leuprorelin Acetate Microspheres for injection for three times, 3.75 mg/time, once every 4 weeks, the initial administration started from the 3 d of the menstrual cycle. Patients in the treatment group were po administered with Xiaojin Tablets on the basis of the control group, 2 tablets/time, twice daily. Patients in two groups were treated for 3 months. After treatment, the clinical efficacy was evaluated, and the improvement of main symptoms and signs, and the level of FSH, LH, E2, LBV, EAI, HCT, TNF-α, MCP-1 and CA125 in two groups before and after treatment was compared. Results After treatment, the clinical efficacy and in the control and treatment groups was 82.2% and 95.6% respectively, and there were differences between two groups (P<0.05). After treatment, the VAS scores of dysmenorrhea, pelvic pain, coital pain in two groups were significantly decreased (P<0.05), the pelvic mass diameter and uterine volume were significantly reduced (P<0.05), and the improvement effect of the main symptoms and signs in the treatment group was significantly better than those in the control group (P<0.05). After treatment, the level of FSH, LH and E2 in two groups was significantly decreased (P<0.05), and which in the treatment group was significantly lower than that in the control group (P<0.05). After treatment, the level of LBV, EAI and HCT in the treatment group was significantly lower than that in the control group (P<0.05). After treatment, the serum level of TNF-α, MCP-1 and CA125 in two groups was significantly decreased (P<0.05), and which in the treatment group was significantly lower than that in the control group (P<0.05). Conclusion Xiaojin Tablets combined with leuprorelin in treatment of endometriosis can relieve the related symptoms and signs, regulate reproductive endocrine function, improve the body's congestion and inflammation, has remarkable overall effect with good safety and reliability.

R984