[关键词]
[摘要]
目的 研究鸦胆子油软胶囊联合SOX方案(奥沙利铂+替吉奥)治疗晚期结直肠癌的临床疗效。方法 选取2018年8月-2019年8月在郑州大学附属洛阳中心医院治疗的80例晚期结直肠癌患者,所有患者随机分为对照组和治疗组,每组各40例。对照组患者入院后给予SOX方案治疗,第1~14天给予注射用奥沙利铂,推荐剂量130 mg/m2,溶于500 mL 5%葡萄糖溶液中,输注时间小于3 h;第1~21天口服替吉奥胶囊,1粒/次,2次/d。治疗组在对照组基础上口服鸦胆子油软胶囊,4粒/次,3次/d。21 d为1个治疗疗程,两组患者接受治疗3个疗程。观察两组的临床疗效,比较Karnofsky(KPS)评分、生活质量(QOL)评分及血清癌胚抗原(CEA)、基质金属蛋白酶(MMP)-2和MMP-9水平。结果 经过治疗后,治疗组客观缓解率(ORR)和疾病控制率(CBR)显著高于对照组(P<0.05)。治疗后,两组患者KPS评分和QOL评分显著升高(P<0.05),且治疗组KPS评分和QOL评分升高程度较大(P<0.05)。治疗后,两组CEA、MMP-2和MMP-9水平显著降低(P<0.05);并且治疗组降低较多(P<0.05)。治疗组胃肠道反应、血小板减少、白细胞减少和转氨酶升高等不良反应发生率明显低于对照组(P<0.05)。结论 鸦胆子油软胶囊联合SOX方案治疗晚期结直肠癌具有较好的治疗效果,能够提高患者生活质量,降低肿瘤标志物水平,安全性较高,值得在临床上推广应用。
[Key word]
[Abstract]
Objective To study the clinical efficacy of Yadanzi Oil Soft Capsules combined with SOX chemotherapy regimen (Oxaliplatin + Tegafur, Gimeracil and Oteracil Potassium) in treatment of advanced colorectal cancer. Methods Patients (80 cases) with advanced colorectal cancer in Luoyang Central Hospital Affiliated to Zhengzhou University from August 2018 to August 2019 were randomly divided into control and treatment groups, and each group had 40 cases. Patients in the control group were given SOX chemotherapy regimen, and patients were iv administered with Oxaliplatin for injection at 1-14 d, 130 mg/m2 added into 5% glucose solution 500 mL, infusion time was less than 3 h; and at 1-14 d, patients were po administered with Gimeracil and Oteracil Porassium Capsules, 1 grain/time, twice daily. Patients in the treatment group were po administered with Yadanzi Oil Soft Capsules on the basis of the control group, 4 grains/time, three times daily. A course of treatment had 21 d, and patients in two groups were treated for 3 courses. After treatment, the clinical efficacies were evaluated, and KPS score, QOL score, the levels of CEA, MMP-2, and MMP-9 in two groups were compared. Results After treatment, ORR and CBR in the treatment group were significantly higher than those in the control group, and there were differences between two groups (P<0.05). After treatment, KPS score and QOL score in the two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05), and KPS score and QOL score in the treatment group was significantly higher than those in the control group (P<0.05). After treatment, the levels of CEA, MMP-2, and MMP-9 in the two groups were significantly decreased (P<0.05), and the serum tumor markers in the treatment group was significantly lower than those in the control group (P<0.05). The incidence of gastrointestinal reaction, thrombocytopenia, leucopenia, and transaminase elevation in the treatment group was significantly lower than that in the control group, and there was difference between two groups (P<0.05). Conclusion Yadanzi Oil Soft Capsules combined with SOX chemotherapy regimen has clinical curative effect in treatment of advanced colorectal cancer, can improve the quality of life of patients, reduce the level of tumor markers, with good safety, which is worthy of clinical application.
[中图分类号]
R979.2
[基金项目]