目的 研究白芍总苷胶囊联合醋酸泼尼松片治疗类风湿关节炎的临床疗效。方法 选取2019年1月-2019年10月在天津市人民医院治疗的70例类风湿关节炎患者，将所有患者随机分为对照组和治疗组，每组各35例。对照组患者口服醋酸泼尼松片，10 mg/次，2次/d。治疗组在对照组基础上口服白芍总苷胶囊，2粒/次，3次/d。两组患者持续治疗3个月。观察两组的临床疗效，比较两组的关节肿胀分级、20 m步行时间、视觉模拟评分（VAS）评分、病情活动度评价表（DAS28）评分、血清炎性因子水平。结果 治疗后，对照组和治疗组的总有效率分别为77.14%、94.29%，两组比较差异有统计学意义（P<0.05）。治疗后，两组患者关节肿胀分级情况显著好转，20 m步行时间显著缩短（P<0.05），且治疗组改善程度较大（P<0.05）。治疗后两组患者VAS评分和DAS28评分均显著降低（P<0.05）；且治疗组VAS评分和DAS28评分降低更显著（P<0.05）。治疗后，两组类风湿因子（RF）、红细胞沉降率（ESR）和C反应蛋白（CRP）水平均显著降低（P<0.05）；并且治疗组血清炎性因子降低较多（P<0.05）。结论 白芍总苷胶囊联合醋酸泼尼松片治疗类风湿关节炎具有较好的疗效，能够改善患者临床症状，缓解关节肿胀度和疼痛度，降低血清炎性因子水平，安全性较高，值得在临床上推广应用。

Objective To study the efficacy of Total Glucosides of White Paeony Capsules combined with Prednisone Acetate Tablets in treatment of rheumatoid arthritis. Methods Patients (70 cases) with rheumatoid arthritis in Tianjin Union Medical Center from January 2019 to October 2019 were randomly divided into control and treatment groups, and each group had 35 cases. Patients in the control group were po administered with Prednisone Acetate Tablets, 10 mg/time, twice daily. Patients in the treatment group were po administered with Total Glucosides of White Paeony Capsules on the basis of the control group, 2 grains/time, three times daily. Patients in two groups were treated for 3 months. After treatment, the clinical efficacies were evaluated, and joint swelling classification, 20 m walking time, VAS score, DAS28 score, and serum level of inflammatory factor in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 77.14% and 94.29%, respectively, and there was difference between two groups (P<0.05). After treatment, the grade of joint swelling in two groups were significantly improved, but 20 m walking time in two groups were significantly shortened, with significant difference between two groups (P<0.05). And the observational indexes in the treatment group were significantly better than those in the control group (P<0.05). After treatment, VAS score and DAS28 score in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the VAS score and DAS28 score in the treatment group were significantly lower than those in the control group (P<0.05). After treatment, RF, ESR, and CRP in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the serum levels of inflammatory factors in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). Conclusion Total Glucosides of White Paeony Capsules combined with Prednisone Acetate Tablets has clinical curative effect in treatment of rheumatoid arthritis, can improve the clinical symptoms of patients, relieve the degree of joint swelling and pain, and reduce the serum level of inflammatory factors, with good safety, which is worthy of clinical application.

R976