[关键词]
[摘要]
目的 探讨解郁丸联合度洛西汀治疗卒中后抑郁的临床疗效。方法 选取南阳南石医院2016年1月-2018年12月收取的卒中后抑郁患者136例,随机分为对照组和治疗组,每组各68例。对照组口服盐酸度洛西汀肠溶片,起始剂量40 mg/d,1周后调整为60 mg/d。治疗组在对照组基础上口服解郁丸,4 g/次,3次/d。两组疗程均为8周。观察两组患者临床疗效,同时比较治疗前后两组患者汉密尔顿抑郁量表(HAMD)评分,及血清去甲肾上腺素(NE)、5-羟色胺(5-HT)、P物质(SP)和神经肽Y(NPY)水平。结果 治疗后,对照组和治疗组临床有效率分别为76.47%和91.18%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者HAMD评分显著低于治疗前(P<0.05),且治疗组明显高于对照组(P<0.05)。治疗后,两组患者血清5-HT、NE和NPY水平均显著高于治疗前(P<0.05),而SP水平显著降低(P<0.05),且治疗组患者血清5-HT、NE、NPY和SP水平明显好于对照组(P<0.05)。结论 解郁丸联合度洛西汀治疗卒中后抑郁患者,可显著升高血清5-HT、NE、NPY水平和降低SP水平,疗效显著,安全性好。
[Key word]
[Abstract]
Objective To observe the efficacy of Jieyu Pills combined with duloxetine in treatment of post-stroke depression. Methods Patients (136 cases) with post-stroke depression in Nanshi Hospital of Nanyang from January 2016 to December 2018 were randomly divided into control and treatment groups, and each group had 68 cases. Patients in the control group were po administered with Duloxetine Hydrochloride Enteric-coated Tablets, the initial dose was 40 mg/d, and then adjusted to 60 mg/d after one week. Patients in the treatment group were po administered with Jieyu Pills on the basis of the control group, 4 g/time, three times daily. Patients in two groups were treated for 8 weeks. After treatment, the clinical efficacy was evaluated, and the HAMD score, the serum level of NE, 5-HT, SP and NPY in two groups before and after treatment were compared. Results After treatment, the clinical efficacy and in the control and treatment groups was 76.47% and 91.18% respectively, and there were differences between two groups (P<0.05). After treatment, the HAMD score in two groups was significantly decreased (P<0.05), and which in the treatment group was significantly lower than that in the control group (P<0.05). After treatment, the serum level of NE, 5-HT, and NPY in two groups was significantly increased (P<0.05), but the SP level was significantly decreased (P<0.05), and the serum level of NE, 5-HT, SP, and NPY in the treatment group was significantly better than that in the control group (P<0.05). Conclusion Jieyu Pills combined with duloxetine in treatment of post-stroke depression can significantly increase the serum level of NE, 5-HT and NPY, reduce the SP level, which has significant curative effect and good safety.
[中图分类号]
R971
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