目的 探讨复方牙痛酊联合浓替硝唑含漱液治疗牙周炎的临床疗效。方法 选取2018年6月-2019年12月河南大学赛思口腔医院收治的80例牙周炎患者作为研究对象，按照随机数字表法将所有患者分为对照组（38例）和治疗组（42例），各包括45颗患牙。对照组给予浓替硝唑含漱液，2 mL溶于50 mL温水充分稀释后，含漱1 min，3次/d。治疗组在对照组基础上于患处涂抹复方牙痛酊，3次/d。两组患者连续治疗10 d。观察两组的临床疗效，比较两组的牙周指标[牙龈指数（GI）、出血指数（BI）、菌斑指数（PLI）]、龈沟液中C反应蛋白（CRP）、基质金属蛋白酶-9（MMP-9）、单核细胞趋化蛋白-1（MCP-1）、前列腺素E2（PEG2）水平和口腔健康影响程度量表（OHIP-14）评分。结果 治疗后，治疗组患者的总有效率为88.10%，比对照组的71.05%高，差异有统计学意义（P<0.05）。治疗后，两组的GI、BI、PLI评分明显低于治疗前（P<0.05）；治治疗后疗组患者的GI、BI、PLI评分比对照组低，差异有统计学意义（P<0.05）。治疗后，两组龈沟液中的CRP、MMP-9、MCP-1、PEG2水平明显降低（P<0.05），且治疗组降低的更明显，差异有统计学意义（P<0.05）。治疗后，两组的OHIP-14评分显著降低（P<0.05），且治疗后治疗组的OHIP-14评分低于对照组（P<0.05）。结论 复方牙痛酊联合浓替硝唑含漱液治疗牙周炎有较好临床疗效，可减轻牙周症状，降低龈沟液炎症反应，改善患者的生活质量，具有一定的临床研究价值。

Objective To investigate the clinical effect of Compound Yatong Tincture combine with Concentrated Tinidazole Gargles in treatment of periodontitis. Methods Patients (80 cases) with periodontitis in SATH Hospital of Stomatology Henan University from June 2018 to December 2019 were randomly divided into the control group (38 cases) and the treatment group (42 cases), and each group had 45 teeth. Patients in the control group were given Concentrated Tinidazole Gargles, 2 mL added into warm water 50 mL, rinsed for 1 min, three times daily. Patients in the treatment group smear Compound Yatong Tincture in the affected area on the basis of the control group, three times daily. Patients in two groups were treated for 10 d. After treatment, the clinical efficacies were evaluated, and periodontal indexes (GI, BI, and PLI), the levels of CRP, MMP-9, MCP-1, and PEG2, and the OHIP-14 score in two groups were compared. Results After treatment, the total effective rate of the treatment group (88.10%) was higher than that in the control group (71.05%) (P<0.05). After treatment, the scores of GI, BI, and PLI in the two groups were significantly lower than those before treatment (P<0.05). And the scores of GI, BI, and PLI in the treatment group were lower than those in the control group (P<0.05). After treatment, the levels of CRP, MMP-9, MCP-1, and PEG₂ in the gingival crevicular fluid of the two groups were significantly decreased (P<0.05), and the periodontal indexes in treatment group were significantly lower than those in the control group, the difference was statistically significant (P<0.05). After treatment, the OHIP-14 score in the two groups were significantly decreased (P<0.05), and the OHIP-14 scores in the treatment group were lower than those of the control group (P<0.05). Conclusion Compound Yatong Tincture combine with Concentrated Tinidazole Gargles has clinical curative effect in treatment of periodontitis, can alleviate periodontal symptoms, reduce inflammation of gingival crevicular fluid, and improve the quality of life of patients, which has a certain clinical research value.

R988.2

河南省医学科技攻关计划项目（2018020863）