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[摘要]
目的 分析2016-2019年淮南新华医疗集团新华医院新生儿科重症监护室感染性疾病病原菌的分布及耐药性。方法 回顾性分析2016年1月-2019年4月淮南新华医疗集团新华医院新生儿科重症监护室的病原菌分布情况和耐药性。结果 共检测出病原菌221株,其中革兰阳性菌78株,构成比为35.29%,主要为肺炎链球菌、金黄色葡萄球菌和表皮葡萄球菌;革兰阴性菌143株,构成比为64.71%,主要为肺炎克雷伯菌、大肠埃希菌和铜绿假单胞菌。肺炎链球菌对复方磺胺甲唑和红霉素的耐药率最高,为91.67%,对头孢吡肟、万古霉素的耐药率最低,为0.00%。金黄色葡萄球菌对青霉素的耐药率最高,为90.00%,对万古霉素、头孢吡肟、头孢曲松和头孢唑林的耐药率最低,为0.00%。表皮葡萄球菌对红霉素、青霉素和氨苄西林的耐药率最高,为100.00%,对万古霉素的耐药率最低,为0.00%。肺炎克雷伯菌对亚胺培南的耐药率最低,为0.00%,对氨苄西林的耐药率最高,为97.96%;大肠埃希菌对美罗培南、亚胺培南的耐药率最低,为0.00%,对氨苄西林的耐药率最高,为94.29%;铜绿假单胞菌对舒巴坦的耐药率最低,为3.85%,对氨苄西林、头孢呋辛的耐药率最高,为100.00%。结论 淮南新华医疗集团新华医院新生儿科重症监护室感染性疾病所分离的病原菌中以革兰阴性菌为主,多数病原菌都具有较高的耐药性,临床药敏检测和细菌分析对于新生儿重症监护室的抗感染治疗具有重要指导意义,能够显著减少耐药菌的出现,提高治疗效果。
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[Abstract]
Objective To explore the distribution and drug resistance of infectious diseases in the intensive care unit of Department of Neonatology of Xinhua Medical Group Xinhua Hospital from 2016 to 2019. Methods The distribution and drug resistance of pathogens in the intensive care unit of Department of Neonatology of Xinhua Medical Group Xinhua Hospital from January 2016 to April 2019 were retrospectively analyzed. Results A total of 221 strains of pathogenic bacteria were detected. Gram-positive bacteria bacteria were 78 strains (35.29%), and main of them were Streptococcus pneumonia, Staphylococcus aureus, and Staphylococcus epidermidis. Gram-negative bacteria bacteria were 143 strains (64.71%), and main of them were Klebsiella pneumonia, Escherichia coli, and Pseudomonas aeruginosa. The resistance rate of S. pneumoniae against compound sulfamethoxazole and erythromycin was the highest with 91.67%, and the resistance rate against cefepime and vancomycin was the lowest with 0.00%. The highest resistance rate of S. aureus against penicillin was the highest with 90.00%, and the lowest resistance rate against vancomycin, cefepime, ceftriaxone, and cefazolin was 0.00%. The resistance rate of S. epidermidis against erythromycin, penicillin, and ampicillin was the highest with 100.00%, and the resistance rate against vancomycin was 0.00%. The resistance rate of K. pneumoniae against imipenem was the lowest at 0.00%, and the highest rate of resistance against ampicillin was 97.96%. The lowest resistance rate of E. coli against meropenem and imipenem was highest at 0.00%, and the highest resistance rate to ampicillin was 94.29%. The lowest resistance rate of P. aeruginosa against sulbactam was 3.85%, and the highest resistance rate to ampicillin and cefuroxime was 100.00%. Conclusion The pathogens isolated from the intensive care unit of Department of Neonatology of Xinhua Medical Group Xinhua Hospital are mainly Gram-negative bacteria, and most of the pathogens have high drug resistance. Clinical drug sensitivity test and bacterial analysis for the anti-infective treatment of the intensive care unit of Department of Neonatology has important guiding significance, which can significantly reduce the emergence of drug-resistant bacteria and improve the therapeutic effect.
[中图分类号]
R978.1
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