目的 回顾性调查河南省人民医院住院患者使用注射用红花黄色素的超说明书现状，为临床合理用药提供参考。方法 随机选取河南省人民医院2018年1~12月使用注射用红花黄色素的住院患者医嘱1 420例。参照药品说明书，对适应症、用法用量、用药疗程、配伍溶媒、联合用药等合理性进行分析。结果 1 420例医嘱中，1 293例存在不同程度的超说明书用药情况，超说明书用药发生率为91.06%，表现为超适应症（61.76%）、超单次剂量（63.66%）、超用药频次（0.28%）、超疗程（4.44%）、超溶媒量（22.39%）、配伍（0.42%）和溶媒选择不当（12.82%）。结论 注射用红花黄色素的超说明书用药情况广泛存在，建议尽快出台中药注射剂的相关政策，科学化管理，并加强监测与管控，促进临床合理用药。

Objective To investigate the current status of off label medication of Safflor Yellow for injection for inpatients in Henan Provincal People's Hospital in 2018, and provide a reference for clinical rational drug use. Methods 1 420 Orders of inpatients who used Safflor Yellow for injection from January to December 2018 were selected. According to the drug instructions, the rationality of indications, dosage, medication course, compatible solvents, and combined medication were analyzed. Results There were 1 293 off label medication orders in 1 420 cases of prescription, and the incidence rate of off label medication was 91.06%, including over indication (61.76%), over single dose (63.66%), over frequency (0.28%), over course (4.44%), over solvent amounts (22.39%), compatibility (0.42%), and improper solvent(12.82%). Conclusion Safflor Yellow for injection is widely off label used in Henan Provincal People's Hospital. It is suggested that policies for traditional Chinese medicine injection should be issued as soon as possible, monitoring and control management should be strengthened to promote rational use of drugs.

R969.3