目的 了解咸阳市第一人民医院抗感染药物不良反应的发生规律及特点，为合理使用抗感染药物提供依据。方法 对2014-2018年咸阳市第一人民医院上报的162例抗感染药物所致ADR报告进行整理，从患者年龄、药品品种、给药途径以及临床表现等方面进行归纳分析。结果 162例ADR中，中老年患者较易发生ADR，喹诺酮类及头孢菌素类药物发生ADR的例数最多，引发ADR的主要给药途径为静脉给药，ADR主要表现为皮肤及其附件损害。结论 根据ADR发生的规律和特点，应加强抗感染药物的用药监管力度，重点监护特殊人群用药，减少ADR的发生，保障患者安全用药。

Objective To understand the occurrence regularity and characteristics of adverse reactions of anti-infective drugs in the First People's Hospital of Xianyang, and to provide professional and technical basis for rational use of anti-infective drugs. Methods 162 ADR cases caused by anti-infective drugs reported in the First People's Hospital of Xianyang from 2014 to 2018 were sorted out and analyzed from the aspects of patient's age, drug variety, route of administration, and clinical manifestations. Results Among 162 cases of ADR, middle-aged and elderly patients were more prone to ADR. Quinolones and cephalosporins were the most common types of ADR. Intravenous administration was the main route to induce ADR. ADR was mainly manifested by skin and its appendages damage. Conclusion According to the regularity and characteristics of ADR, the supervision of the use of anti-infective drugs should be strengthened to focus on monitoring the use of drugs in special population and ensure the safe use of drugs for patients.

R969.3