目的 探讨抗感颗粒联合帕拉米韦氯化钠注射液治疗儿童流行性感冒的临床疗效。方法 选取2017年5月-2019年5月在资阳市第一人民医院治疗的156例流行性感冒患儿，根据用药的差别分为对照组（78例）和治疗组（78例）。对照组静脉滴注帕拉米韦氯化钠注射液，10 mg/kg，1次/d；治疗组在对照组基础上口服抗感颗粒，10 g/次，3次/d。两组患者均经5 d治疗。观察两组患者临床疗效，同时比较治疗前后两组患者临床症候积分及血清C反应蛋白（CRP）、白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）、干扰素-γ（IFN-γ）和降钙素原（PCT）水平。结果 治疗后，对照组和治疗组临床有效率分别为84.62%、98.72%，两组比较差异有统计学意义（P<0.05）。经治疗，两组症候积分显著降低（P<0.05），且治疗组比对照组降低更明显。经治疗，两组患者血清CRP、IL-6、TNF-α、IFN-γ、PCT水平明显均下降（P<0.05），且治疗组患者比对照组降低更明显（P<0.05）。结论 抗感颗粒联合帕拉米韦氯化钠注射液治疗儿童流行性感冒可有效改善患儿临床症状，降低机体炎症反应，增强机体免疫功能，具有一定的临床推广应用价值。

Objective To explore the clinical efficacy of Kanggan Granules combined with Peramivir and Sodium Chloride Injection in treatment of influenza in children. Methods Children (156 cases) with influenza in the First People's Hospital of Ziyang from May 2017 to May 2019 were divided into control (78 cases) and treatment (78 cases) groups based on different treatments. Children in the control group were iv administered with Peramivir and Sodium Chloride Injection, 10 mg/time, once daily. Children in the treatment group were po administered with Kanggan Granules on the basis of the control group, 10 g/time, three times daily. Children in two groups were treated for 5 d. After treatment, the clinical efficacy was evaluated, and the clinical symptom score and the serum level of CRP, IL-6, TNF-α, IFN-γ and PCT in two groups before and after treatment were compared. Results After treatment, the clinical efficacy and in the control and treatment groups was 84.62% and 98.72%, respectively, and there were differences between two groups (P<0.05). After treatment, the clinical symptom score in two groups was significantly decreased (P<0.05), and the score in the treatment group was significantly lower than that in the control group (P<0.05). After treatment, the serum level of CRP, IL-6, TNF-α, IFN-γ, and PCT in two groups was significantly decreased (P<0.05), and the inflammatory factors level in the treatment group was significantly lower than that in the control group (P<0.05). Conclusion Kanggan Granules combined with Peramivir and Sodium Chloride Injection in treatment of children influenza can effectively improve the clinical symptoms of children, reduce the body's inflammatory response, and enhance the body's immune function, which has a certain clinical application value.

R985