目的 观察和分析小儿肺热清颗粒联合头孢呋辛酯干混悬剂治疗小儿急性支气管炎的临床疗效。方法 选择2017年8月-2019年2月在北京市顺义区医院治疗的147例急性支气管炎患儿，随机分为对照组（74例）和治疗组（73例）。对照组口服头孢呋辛酯干混悬剂，0.125 g/次，2次/d。治疗组在对照组基础上口服小儿肺热清颗粒，1~3岁患儿4 g/次，3~7岁患儿6 g/次，7~12岁患儿8 g/次，3次/d。两组均治疗10 d。观察两组患者临床疗效，同时比较治疗前后两组患者血清白细胞介素-4（IL-4）、超敏C反应蛋白（hs-CRP）和肿瘤坏死因子-α（TNF-α）水平及症状消失时间。结果 治疗后，对照组和治疗组临床有效率分别为79.73%、93.15%，两组比较差异有统计学意义（P<0.05）。治疗后，两组患者血清IL-4、hs-CRP和TNF-α均明显降低（P<0.05），且治疗组IL-4、hs-CRP和TNF-α明显比对照组低（P<0.05）。治疗后，治疗组肺部啰音、咳嗽和发热消失时间明显短于对照组（P<0.05）。结论 小儿肺热清颗粒联合头孢呋辛酯干混悬剂治疗小儿急性支气管炎，可明显改善患儿炎症水平，迅速缓解临床症状，具有较好的治疗效果，安全可靠。

Objective To analyze the clinical effect of Xiaoer Feireqing Granules combined with Cefuroxime Axetil for suspension in treatment of acute bronchitis in children. Methods Children (147 cases) with acute bronchitis in Beijing Shunyi District Hospital from August 2017 to February 2019 were randomly divided into control (74 cases) and treatment (73 cases) groups. Children in the control group were po administered with Cefuroxime Axetil for suspension, 0.125 g/time, twice daily. Children in the treatment group were po administered with Xiaoer Feireqing Granules on the basis of the control group, 4 g/time for 1-3 years old children, 6 g/time for 3-7 years old, 8 g/time for 7-12 years old, three times daily. Children in two groups were treated for 10 d. After treatment, the clinical efficacy was evaluated, and the serum level of IL-4, hs-CRP, TNF-α, and the time of symptoms disappear in two groups before and after treatment were compared. Results After treatment, the clinical efficacy and in the control and treatment groups was 79.73% and 93.15%, respectively, and there were differences between two groups (P<0.05). After treatment, the serum level of IL-4, hs-CRP, and TNF-α in two groups was significantly decreased (P<0.05), and the level in the treatment group was significantly lower than that in the control group (P<0.05). After treatment, the disappearance time of pulmonary rales, cough and fever in the treatment group was significantly earlier than that in the control group (P<0.05). Conclusion Xiaoer Feireqing Granules combined with Cefuroxime Axetil for suspension in treatment of acute bronchitis in children can significantly improve the inflammatory level and rapidly relieve clinical symptoms, which has good therapeutic effect with high safety and reliability.

R974