目的 优选参黛愈疡灌肠液的水提工艺。方法 以苦参碱、氧化苦参碱的提取率和干膏率为评价指标，采用信息熵理论确定各指标权重系数并计算综合评分。以煎煮时间、加水倍数、煎煮次数为考察因素，采用L₉（3⁴）正交试验筛选参黛愈疡灌肠液的最优提取工艺并进行验证。结果 最优的提取工艺为饮片煎煮3次，每次加8倍量水、每次煎煮1 h，苦参碱、氧化苦参碱的平均提取率分别为0.117 1%、0.010 8%，平均干膏率为36.53%。结论 优选的水提工艺重复性好、稳定可行，可为参黛愈疡灌肠液的后续开发和工业化生产提供科学依据。

Objective To optimize the water extraction process of Shendai Yuyang Enema. Methods The extraction rates of matrine and oxymatrine and dry extractum were used as evaluation indexes. Information entropy theory was used to determine the weight of each indicator to calculate comprehensive score. L₉(3⁴) orthogonal design was used to screen the optimal extraction technology of Shendai Yuyang Enema with decoction times, water volume and decoction times as factor. Validation test was also performed. Results The optimal extraction process was extracting third times, adding 8 folds of water, and 1 h each time. The results of validation test showed that the average extraction rate of matrine and oxymatrine were 0.117 1% and 0.010 8%, respectively. The average dry extractum yield was 36.53%. Conclusion The optimized water extraction process is reproducible, stable and feasible. It can provide a scientific basis for the industrial extraction and preparation of Shendai Yuyang enema.

R943

国家中医药管理局全国名老中医药专家传承工作室建设项目；深圳市科技计划项目（ZDSYS201606081515458）