[关键词]
[摘要]
目的 通过大鼠在体单向肠灌流实验研究黄芩汤中黄芩苷在体肠吸收特性。方法 建立大鼠在体单向肠灌流模型,采用质量法计算黄芩苷吸收速率常数(Ka)和有效渗透系数(Peff)。结果 黄芩汤中黄芩苷在十二指肠、空肠、回肠的吸收速率和程度都存在一定差异。其中黄芩苷在十二指肠的吸收速率显著高于空肠段,差异具有统计学意义(P<0.05),略高于回肠段但差异无统计学意义;黄芩苷在十二指肠的吸收程度明显高于空肠段且差异具有统计学意义(P<0.05),略高于回肠段但差异无统计学意义。结论 黄芩汤中黄芩苷在十二指肠的吸收速度和吸收程度较好,表明黄芩汤中黄芩苷在体吸收具有肠道部位依赖特性。
[Key word]
[Abstract]
Objective To study the intestinal absorption characteristics of baicalin in Huangqin decoction by in vivo single intestinal perfusion test. Methods Rat model of in vivo single intestinal perfusion model was established, and the absorption rate constant (Ka) and effective osmotic coefficient (Peff) of baicalin were calculated. Results The absorption rate and degree of baicalin in duodenum, jejunum and ileum were significantly different. The absorption rate of baicalin in duodenum was significantly higher than that in jejunum, and the difference was statistically significant (P<0.05), and it slightly higher than that in ileum, and the difference was not statistically significant. The absorption degree of baicalin in duodenum was significantly higher than that in jejunum, and the difference was statistically significant (P<0.05), but it slightly higher than that in ileum, and the difference was not statistically significant. Conclusion The absorption rate and degree of baicalin in the duodenum of Huangqin Decoction are good, so it indicates that the absorption of baicalin in Huangqin Decoction has intestinal site-dependent characteristics.
[中图分类号]
R966
[基金项目]
成都中医药大学校基金青年教师创新基金(ZRQN1706);成都中医药大学校基金医院专项(2017EL20)