自2019年12月以来，新型冠状病毒（SARS-CoV-2）在国内爆发，并且目前已在日本和韩国等地进入高发态势，该病毒导致的新型冠状病毒肺炎（COVID-19）已造成多人感染并有2 500余人死亡，世界卫生组织于2020年1月31日宣布疫情为"国际关注的突发公共卫生事件"。抗新型冠状病毒药物是阻止病毒传播以及在宿主体内复制从而引起肺炎的有力武器。综述了抗COVID-19药物靶点以及相应的药物和候选物的研究进展。

The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has been in the high incidence since December 2019, and has been in high incidence in Japan and Korea. The corona virus disease 2019 (COVID-19) caused by the virus is likely to cause thousands of people infected and more than 2 500 deaths. On January 31, 2020, the World Health Organization declared the epidemic as Public Health Emergency of International Concern. Anti SARS-CoV-2 drugs are powerful weapons to prevent virus transmission and to cause pneumonia in hosts. Herein, the research progress of the anti SARS-CoV-2 drug targets and related drug candidates were summarized in this papaer.

R974

江苏省基础研究计划面上资助项目（BK20181209）