慢性阻塞性肺疾病（COPD）是呼吸系统疾病中常见的疾病，可引起呼吸衰竭、肺源性心脏病、心力衰竭等严重疾病。噻托溴铵作为长效的抗胆碱制剂，现为临床治疗慢性阻塞性肺炎的常用药物，其可通过扩张支气管、抑制炎症因子和抑制气道重塑的作用机制，进而有效缓解支气管痉挛、呼吸困难和降低炎症反应。主要对噻托溴铵治疗慢性阻塞性肺疾病的作用机制进行综述。

Chronic obstructive pulmonary disease is the common disease of respiratory diseases, which can cause respiratory failure, pulmonary heart disease, heart failure, and other serious diseases. As a long-acting anticholine preparation, tiotropium bromide has commonly used in clinical treatment of chronic obstructive pulmonary disease. It can effectively relieve bronchospasm, dyspnea, and reduce inflammation by dilating bronchus, inhibiting inflammatory factor, and inhibiting airway remodeling. The mechanism of tiotropium bromide in treatment of COPD is reviewed in this paper.

R974

江苏省药学会–天晴（连云港）医院药学科研项目（Q2018070）