目的 探讨强筋健骨胶囊联合依替膦酸二钠片治疗骨质疏松症的临床疗效。方法 选择2018年1月-2019年3月周口市中心医院收治的92例骨质疏松症患者为研究对象，将所有患者按随机数字表法分为对照组和治疗组，每组各46例。对照组口服依替膦酸二钠片，0.2 g/次，2次/d，连续治疗2周后停药11周，13周为1个疗程，共治疗2个周期。治疗组在对照组治疗的基础上口服强筋健骨胶囊，1.2 g/次，2次/d，连续治疗26周。观察两组的临床疗效，比较两组的骨密度（BMD）、骨代谢指标、关节功能指标、疼痛程度。结果 治疗后，对照组和治疗组的总有效率分别为80.43%、93.48%，两组比较差异有统计学意义（P<0.05）。治疗后，治疗组全髋、腰椎、股骨颈的BMD均明显升高，同组治疗前后比较差异具有统计学意义（P<0.05）；且治疗组全髋、腰椎、股骨颈的BMD均明显高于对照组，两组比较差异有统计学意义（P<0.05）。治疗后，两组的Ⅰ型前胶原氨基末端肽（PINP）、Ⅰ型胶原C末端肽（β-CTX）、骨特异性碱性磷酸酶（BALP）水平均明显降低，骨钙素（BGP）水平明显升高，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗后治疗组的PINP、β-CTX、BALP水平均明显低于对照组，BGP水平明显高于对照组，两组比较差异有统计学意义（P<0.05）。治疗后，两组的Oswestry功能障碍指数（ODI）、视觉模拟评分法（VAS）评分均显著降低，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗后治疗组的ODI指数、VAS评分均明显低于对照组，两组比较差异有统计学意义（P<0.05）。结论 强筋健骨胶囊联合依替膦酸二钠片治疗骨质疏松症具有较好的临床疗效，能提高患者的BMD，改善骨代谢指标和关节功能，具有一定的临床研究价值。

Objective To investigate the clinical effect of Qiangjin Jiangu Capsules combined with Etidronate Disodium Tablets in treatment of osteoporosis. Methods Patients (92 cases) with osteoporosis in Zhoukou Central Hospital from January 2018 to March 2019 were randomly divided into control and treatment groups, and each group had 46 cases. Patients in the control group were po administered with Etidronate Disodium Tablets, 0.2 g/time, twice daily. After 2 weeks of continuous treatment, the drug was stopped for 11 weeks, and 13 weeks as a course of treatment, then patients were treated for 2 courses. Patients in the treatment group were po administered with Qiangjin Jiangu Capsules on the basis of the control group, 1.2 g/time, twice daily, and were treated for 26 weeks. After treatment, the clinical efficacies were evaluated, and BMD, bone metabolism indexes, joint function, and degree of pain in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 80.43% and 93.48%, respectively, and there was difference between two groups (P < 0.05). After treatment, the BMD of total hip, lumbar spine, and femoral neck in the treatment group were significantly increased, and the difference was statistically significant in the same group (P < 0.05). And the BMD in the treatment group were significantly higher than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the levels of PINP, β-CTX and BALP in two groups were significantly decreased, but the levels of BGP in two groups were significantly increased, and the difference was statistically significant in the same group (P < 0.05). And the levels of PINP, β-CTX and BALP in the treatment group were significantly lower than those in the control group, but the levels of BGP in the treatment group were significantly higher than those in the control group, with significant difference between two groups (P < 0.05). After treatment, ODI and VAS scores in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the ODI and VAS scores in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Qiangjin Jiangu Capsules combined with Etidronate Disodium Tablets has clinical curative effect in treatment of osteoporosis, can improve BMD, bone metabolism, and joint function, which has a certain clinical application value.

R977