目的 探讨暖宫孕子胶囊联合注射用尿促性素治疗排卵障碍性不孕症的临床疗效。方法 选取2016年1月-2017年1月在南阳市第二人民医院治疗的排卵障碍性不孕症患者80例，根据用药的差别分为对照组（40例）和治疗组（40例）。对照组肌肉注射注射用尿促性素，起始75~150 IU/次，1次/d，一周后根据雌激素水平和卵泡发育情况调整剂量，增加至每日150~225 IU，卵泡成熟后肌内注射绒促性素（HCG）10 000 IU，诱导排卵；治疗组在对照组基础上口服暖宫孕子胶囊，1.28 g/次，3次/d。两组患者均治疗3月。观察两组患者临床疗效，同时比较治疗前后两组患者子宫内膜厚度、卵泡直径，孕酮（P）、雌二醇（E2）、促卵泡成熟激素（FSH）和促黄体生成素（LH）水平，SAS和SDS评分及排卵率和妊娠率。结果 治疗后，对照组和治疗组临床有效率分别为80.00%和97.50%，两组比较差异有统计学意义（P<0.05）。经治疗，两组患者子宫内膜厚度、卵泡直径均明显增加（P<0.05），且以治疗组比对照组增加更明显（P<0.05）。治疗后，两组患者FSH、P、E2水平均明显升高（P<0.05），而LH水平显著下降（P<0.05），且治疗组性激素水平明显好于对照组（P<0.05）。经治疗，两组患者SAS、SDS评分均明显下降（P<0.05），且以治疗组降低最明显（P<0.05）。经治疗，对照组排卵率、妊娠率分别为67.5%、27.5%，分别显著低于治疗组的82.5%和42.5%，两组比较差异具有统计学意义（P<0.05）。结论 暖宫孕子胶囊联合注射用尿促性素治疗排卵障碍性不孕症可有效增加子宫内膜厚度，缓解负面情绪，改善机体性激素水平，促进排卵功能，提高妊娠率。

Objective To explore the clinical efficacy of Nuangong Yunzi Capsules combined with urogenin in treatment of ovulatory infertility. Methods Patients (80 cases) with ovulatory infertility in Nanyang Second General Hospital from January 2016 to January 2017 were divided into control (70 cases) and treatment (70 cases) groups based on different treatments. Patients in the control group were im administered with Menotrophin for injection, the initial dose was 75-150 IU/time, once daily, then the dosage was adjusted to 150-225 IU/d according to the estrogen level and follicular development after one week, and ovulation was induced by intramuscular injection of 10 000 IU HCG after follicular maturation. Patients in the treatment group were po administered with Nuangong Yunzi Capsules on the basis of the control group, 1.28 g/time, three times daily. Patients in two groups were treated for 3 months. After treatment, the clinical efficacy was evaluated, and the endometrial thickness, follicular diameter, P, E2, FSH and LH levels, SAS and SDS scores, ovulation rate and pregnancy rate in two groups before and after treatment were compared. Results After treatment, the clinical efficacy and in the control and treatment groups was 80.00% and 97.50%, respectively, and there were differences between two groups (P < 0.05). After treatment, the endometrial thickness and follicular diameter in two groups were significantly increased (P < 0.05), and which in the treatment group were significantly better than those in the control group (P < 0.05). After treatment, the FSH, P and E2 levels in two groups were significantly increased (P < 0.05), but the LH levels were significantly decreased (P < 0.05), and these sex hormone levels in the treatment group were significantly better than those in the control group (P < 0.05). After treatment, the SAS and SDS scores in two groups were significantly decreased (P < 0.05), and which in the treatment group were significantly lower than those in the control group (P < 0.05). After treatment, the ovulation rate and pregnancy rate in the control group were 67.5% and 27.5%, which were significantly lower than 82.5% and 42.5% in the treatment group, respectively, and there were differences between two groups (P < 0.05). Conclusion Nuangong Yunzi Capsules combined with urogenin in treatment of ovulatory infertility can effectively increase the thickness of endometrium, relieve negative emotions, improve the body's sex hormone level, promote ovulation function and increase pregnancy rate.

R984