目的 探讨妇宁胶囊联合地屈孕酮片治疗月经不调疗的临床疗效。方法 选择2017年4月-2018年4月在成都市双流区第一人民医院治疗的月经不调患者142例，根据用药的差别分为对照组（71例）和治疗组（71例）。对照组口服地屈孕酮片，10 mg/次，2次/d；治疗组在对照组基础上口服妇宁胶囊，1.4 g/次，2次/d。两组均于月经第5天开始用药，用药21 d停药，此为1个周期，均经过2个月经周期治疗。观察两组患者临床疗效，同时比较治疗前后两组患者PBAC、HPS、ChQOL和中医症候评分，以及血清雌二醇（E2）、黄体生成激素（LH）、促卵泡成熟激素（FSH）和孕酮（P）水平。结果 治疗后，对照组临床有效率为83.10%，显著低于治疗组的97.18%，两组比较差异有统计学意义（P<0.05）。经治疗，两组患者PBAC评分和中医症候评分均显著降低（P<0.05），但ChQOL评分、HPS评分显著升高（P<0.05），且以治疗组患者这些评分改善更明显（P<0.05）。经治疗，两组患者血清E2、P水平均每组升高（P<0.05），而LH、FSH水平均明显下降（P<0.05），且以治疗组患者改善更明显（P<0.05）。结论 妇宁胶囊联合地屈孕酮片治疗月经不调疗可有效改善患者临床症状，改善机体性激素水平，减少月经失血量，提高患者生活质量。

Objective To explore the clinical effect of Funing Capsules combined with didrogesterone in treatment of menstrual irregularity. Methods Patients (142 cases) with menstrual irregularity in First People's Hospital of Shuangliu District from April 2017 to April 2018 were divided into control (71 cases) and treatment (71 cases) groups based on different treatments. Patients in the control group were po administered with Didrogesterone Tablets, 10 mg/time, twice daily. Patients in the treatment group were po administered with Funing Capsules on the basis of the control group, 1.4 g/time, twice daily. Patients in two groups were treated on the 5th day of menstruation and withdrawn after 21 d, which was one treatment cycle, and they were treated for 2 menstrual cycles. After treatment, the clinical efficacy was evaluated, and the PBAC, HPS, ChQOL and TCM syndrome scores, and the serum levels of E2, LH, FSH and P in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 83.10%, which was significantly lower than 97.18% in the treatment group, and there were differences between two groups (P < 0.05). After treatment, the PBAC and TCM syndrome scores in two groups were significantly decreased (P < 0.05), but ChQOL and HPS scores were significantly increased (P < 0.05), and these scores in the treatment group were significantly better than those in the control group (P < 0.05). After treatment, the serum levels of E2 and P in two groups were significantly increased (P < 0.05), but the LH and FSH levels were significantly decreased (P < 0.05), and these indexes in the treatment group were significantly better than those in the control group (P < 0.05). Conclusion Funing Capsules combined with didrogesterone in treatment of menstrual irregularity can effectively improve the clinical symptoms, the level of sex hormones, reduce menstrual blood loss, and improve the quality of life.

R984