[关键词]
[摘要]
目的 探讨糖尿乐胶囊联合地特胰岛素注射液治疗2型糖尿病的临床疗效。方法 选取2018年5月-2019年5月在大连市第五人民医院治疗的2型糖尿病患者86例,根据用药的差别分为对照组(43例)和治疗组(43例)。对照组皮下注射地特胰岛素注射液,0.1~0.2 U/kg/次,1次/d;治疗组在对照组基础上口服糖尿乐胶囊,1.2 g/次,3次/d。两组患者均治疗4周。观察两组患者临床疗效,同时比较治疗前后两组患者血糖相关指标、血清学指标、血糖波动情况和氧化应激指标。结果 治疗后,对照组和治疗组临床有效率分别为81.40%和97.67%,两组比较差异有统计学意义(P<0.05)。经治疗,两组患者空腹血糖(FBG)、糖化血红蛋白(HbA1c)、餐后2 h血糖(2 h PG)、胰岛素(FINS)、超敏C反应蛋白(hs-CRP)、γ-谷氨酰转移酶(γ-GT)、人颗粒蛋白前体(PGRN)、瘦素(LP)、血糖标准差(SDBG)、平均血糖波动幅度(MAGE)、24 h血糖波动次数(NGE)、24 h血糖平均绝对差(MODD)和丙二醛(MDA)水平均显著下降(P<0.05),而脂联素(APN)、分泌型卷曲相关蛋白5(SFRP5)、谷胱甘肽过氧化物酶(GSH-PX)和超氧化物歧化酶(SOD)水平均显著升高(P<0.05),且治疗组这些指标较对照组改善更明显(P<0.05)。结论 地特胰岛素注射液联合糖尿乐胶囊治疗2型糖尿病能够明显效控制血糖,促进机体氧化应激状态的改善。
[Key word]
[Abstract]
Objective To explore the clinical effect of Tangniaole Capsules combined with dexter insulin in treatment of type 2 diabetes mellitus. Methods Patients (86 cases) with type 2 diabetes mellitus in Dalian Fifth People's Hospital from May 2018 to May 2019 were divided into control (43 cases) and treatment (43 cases) groups based on different treatments. Patients in the control group were sc administered with Dexter Insulin Injection, 0.1-0.2 U/kg/time, once daily. Patients in the treatment group were po administered with Tangniaole Capsules on the basis of the control group, 1.2 g/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacy was evaluated, and the glucose related indicators, serological indexes, blood glucose fluctuation and oxidative stress indexes in two groups before and after treatment were compared. Results After treatment, the clinical efficacy and in the control and treatment groups was 81.40% and 97.67% respectively, and there were differences between two groups (P < 0.05). After treatment, the FPG, HbAlc, 2 h PG, FINS, hs-CRP, γ-GT, PGRN, LP, SDBG, MAGE, NGE, MODD and MDA levels in two groups were significantly decreased (P < 0.05), but the APN, SFRP5, GSH-Px, and SOD levels were significantly increased (P < 0.05), and these indexes levels in the treatment group were significantly better than those in the control group (P < 0.05). Conclusion Tangniaole Capsules combined with dexter insulin in treatment of type 2 diabetes mellitus can effectively control blood glucose, and promote the improvement of oxidative stress.
[中图分类号]
R977
[基金项目]