目的 研究王氏保赤丸联合布拉氏酵母菌散治疗小儿腹泻的临床疗效。方法 选取2016年9月-2019年9月来天津市儿童医院治疗的85例腹泻患儿，将所有患儿随机分为对照组（n=42）和治疗组（n=43）。对照组患儿口服布拉氏酵母菌散，1袋/次，3岁以下儿童1次/d，3岁以上儿童2次/d；治疗组患儿在对照组治疗的基础上口服王氏保赤丸，6个月以内婴儿：5丸/次，6个月至2周岁：每超过1个月加1丸，2~6岁：每超过半岁加5丸，1次/d。两组患儿持续治疗7 d。观察两组患者临床疗效，并比较治疗前后两组患者临床症状改善时间、血清锌、免疫因子水平、血清炎性因子水平变化情况。结果 治疗后，对照组、治疗组总有效率分别为76.19%、95.35%，治疗组总有效率显著较高（P<0.05）。治疗后，治疗组大便恢复时间、体温恢复时间、呕吐消失时间明显短于对照组（P<0.05）。治疗后，两组患儿血清锌、免疫球蛋白A（IgA）、免疫球蛋白G（IgG）、CD4⁺/CD8⁺水平均显著升高（P<0.05）；且治疗组血清锌、免疫因子水平较高（P<0.05）。治疗后，两组患儿超敏C反应蛋白（hs-CRP）、肿瘤坏死因子（TNF）-α、白介素（IL）-6水平均显著降低（P<0.05）；并且治疗组血清炎性因子水平降低较多（P<0.05）。结论 王氏保赤丸联布拉氏酵母菌散治疗小儿腹泻具有较好的治疗效果，可以改善临床症状，降低炎症因子水平，值得在临床上推广应用。

Objective To study the effect of Wangshi Baochi Pills combined with Saccharomyces boulardii Sachets in treatment of infantile diarrhea. Methods Children (85 cases) with infantile diarrhea in Tianjin Children's Hospital from September 2016 to September 2019 were randomly divided into control (42 cases) and treatment (43 cases) groups. Children in the control group were po administered with Saccharomyces boulardii Sachets, 1 bag/time, once or twice daily to children below or above 3 years. Children in the treatment group were po administered with Wangshi Baochi Pills on the basis of the control group, once daily. And infants within 6 months:5 pills/time, 6 months to 2 years old:1 pill per month, and 2-6 years old:5 pills per half year. Children in two groups were treated for 7 d. After treatment, the clinical efficacy was evaluated, and the clinical symptom improvement time, serum zinc, levels of immune factors, and serum inflammatory factors in two groups were compared. Results After treatment, the effective rate of the treatment group (95.35%) was significantly higher than that (76.19%) of the control group (P < 0.05). After treatment, the recovery time of stool, body temperature, and disappearance time of vomiting in the treatment group were significantly shorter than those in the control group (P < 0.05). After treatment, serum zinc, IgA, IgG, and CD4⁺/CD8⁺ levels in two groups were significantly increased (P < 0.05). After treatment, serum zinc and immune factors in the treatment group were higher than those in the control group (P < 0.05). After treatment, the levels of TNF-α, IL-6, and hs-CRP in two groups were significantly decreased (P < 0.05). After treatment, levels of serum inflammatory factors in the treatment group were lower than those in the control group (P < 0.05). Conclusion Wangshi Baochi Pills combined with Saccharomyces boulardii Sachets has good clinical effect in treatment of infantile diarrhea, and can significantly improve clinical symptoms and reduce the level of inflammatory factors, which has a certain clinical application value.

R985