[关键词]
[摘要]
目的 探讨小儿清热片联合康复新液治疗儿童口腔溃疡的临床效果。方法 选取2016年1月-2019年1月北京儿童医院收治的86例口腔溃疡患儿,随机分成对照组(43例)和治疗组(43例)。对照组餐后含漱康复新液5 min后吐出,10 mL/次,3次/d。治疗组在在对照组基础上口服小儿清热片,2片/次,2次/d。两组均连续治疗5 d。观察两组患儿临床疗效,同时比较治疗前后两组患儿主要症状积分、退热时间、食欲改善时间,外周血白细胞计数(WBC)、中性粒细胞绝对值(NEUT#)水平,以及唾液中肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)、表皮生长因子(EGF)水平。结果 治疗后,对照组和治疗组临床有效率分别为86.0%、100.0%,两组比较差异有统计学意义(P<0.05)。治疗后,两组患儿溃疡面积、充血程度、疼痛积分均显著低于治疗前(P<0.05),且治疗组下降更显著(P<0.05)。治疗后,治疗组完全退热时间、食欲改善时间较对照组均显著缩短(P<0.05)。治疗后,两组患儿外周血WBC、NEUT#水平较治疗前均显著降低(P<0.05),且治疗组以上血象指标的改善效果比对照组更显著(P<0.05)。治疗后,两组患儿唾液中TNF-α、IL-6、EGF水平均显著下降(P<0.05),且治疗组上述唾液指标水平均显著低于对照组(P<0.05)。结论 小儿清热片联合康复新液治疗儿童口腔溃疡的疗效确切,能有效缓解患儿症状,迅速退热,改善食欲,加速溃疡愈合,减少复发,且安全性好。
[Key word]
[Abstract]
Objective To investigate the clinical effect of Xiaoer Qingre Tablets combined with Kangfuxin Liquid in treatment of oral ulcer in children. Methods Children (86 cases) with oral ulcer in Beijing Children 's Hospital from January 2016 to January 2019 were randomly divided into control (43 cases) and treatment (43 cases) groups. Children in the control group were gargled administered with Kangfuxin Liquid after meals for 5 min, 10 mL/time, three times daily. Children in the treatment group were po administered with Xiaoer Qingre Tablets on the basis of the control group, 2 tablets/time, twice daily. Children in two groups were treated for 5 d. After treatment, the clinical efficacy was evaluated, and the main symptom scores, the antipyretic time and improvement time of appetite, the level of WBC and NEUT# in peripheral blood, the level of TNF-α, IL-6 and EGF in saliva in two groups before and after treatment were compared. Results After treatment, the clinical efficacy and in the control and treatment groups was 86.0% and 100.0% respectively, and there were differences between two groups (P < 0.05). After treatment, the scores of ulcer area, hyperemia and pain in two groups were significantly decreased (P < 0.05), and the scores in the treatment group were significantly lower than those in the control group (P < 0.05). After treatment, the antipyretic time and improvement time of appetite in the treatment group was significantly shorter than that in the control group (P < 0.05). After treatment, the level of WBC and NEUT# in peripheral blood in two groups was significantly decreased (P < 0.05), and the level of TNF-α, IL-6 and EGF in saliva in two groups was significantly decreased (P < 0.05), and these indexes in the treatment group were significantly lower than those in the control group (P < 0.05). Conclusion Xiaoer Qingre Tablets combined with Kangfuxin Liquid has definite curative effect in treatment of oral ulcer in children, can effectively relieve the symptoms, rapidly reduce fever, improve appetite, accelerate ulcer healing, reduce recurrence, and has good safety.
[中图分类号]
R985
[基金项目]