目的 探讨清喉利咽颗粒联合克拉霉素缓释片治疗慢性咽炎的临床疗效。方法 选取2017年6月-2019年3月在天津医科大学中新生态城医院治疗的176例慢性咽炎患者，根据用药差别分为对照组（88例）和治疗组（88例）。对照组口服克拉霉素缓释片，0.5 g/次，1次/d；治疗组在对照组基础上口服清喉利咽颗粒，5 g/次，3次/d。两组患者均经1周治疗。观察两组患者临床疗效，同时比较治疗前后两组患者临床症状积分、血清C反应蛋白（CRP）、白细胞介素-1β（IL-1β）、血管内皮细胞黏附分子1（VCAM-1）、表皮生长因子（EGF）、白细胞介素-2（IL-2）和分泌型免疫球蛋白A（SIgA）水平。结果 治疗后，对照组临床有效率为81.82%，显著低于治疗组的97.73%，两组比较差异有统计学意义（P<0.05）。经治疗，两组患者临床症状积分均显著降低（P<0.05），且治疗组积分明显低于对照组（P<0.05）。经治疗，两组患者血清CRP、IL-1β和VCAM-1水平明显降低（P<0.05），血清EGF、IL-2、SIgA水平明显升高（P<0.05），且治疗组这些血清细胞因子水平明显好于对照组（P<0.05）。结论 清喉利咽颗粒联合克拉霉素缓释片治疗慢性咽炎可有效改善患者临床症状，降低机体炎症反应，具有一定的临床推广应用价值。

Objective To explore the clinical effect of Qinghou Liyan Granules combined with Clarithromycin Sustained Release Tablets in treatment of chronic pharyngitis. Methods Patients (176 cases) with chronic pharyngitis in SINO-Singapore ECO-City Hospital of Tianjin Medical University from June 2017 to March 2019 were divided into control (88 cases) and treatment (88 cases) groups based on different treatments. Patients in the control group were po administered with Clarithromycin Sustained Release Tablets, 0.5 g/time, once daily. Patients in the treatment group were po administered with Qinghou Liyan Granules on the basis of the control group, 5 g/time, three times daily. Patients in two groups were treated for 1 week. After treatment, the clinical efficacy was evaluated, and the clinical symptom scores, the serum level of CRP, IL-1β, VCAM-1, EGF, IL-2, and SIgA in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 81.82%, which was significantly lower than 97.73% in the treatment group, and there were differences between two groups (P < 0.05). After treatment, the clinical symptom scores in two groups were significantly decreased (P < 0.05), and these indexes in the treatment group were significantly lower than those in the control group (P < 0.05). After treatment, the serum levels of CRP, IL-1β, and VCAM-1 in two groups were significantly decreased (P < 0.05), but the levels of EGF, IL-2 and SIgA were significantly increased (P < 0.05), and these serum cytokine levels in the treatment group were significantly better than that in the control group (P < 0.05). Conclusion Qinghou Liyan Granules combined with clarithromycin can effectively improve the clinical symptoms of chronic pharyngitis, reduce inflammation, which has a certain clinical application value.

R987