胰高血糖素样肽-1是经胰高血糖素原基因编码、肠道L细胞分泌的多肽类物质，在营养物质、细胞因子、神经信号等刺激下通过促进胰岛素的分泌而发挥降糖作用。近年来，胰高血糖素样肽-1受体激动剂在2型糖尿病治疗方面已获肯定，与传统降糖药物相比，其除可以稳定降糖外，还具有减重、降压、调脂、心血管和肾脏保护等益处。主要对GLP-1受体激动剂药理作用的研究进展进行综述。

Glucagon-like peptide-1 is a peptide encoded by proglucagon gen and secreted by intestinal tract L cell, and can reduce blood glucose through secreting enough insulin when stimulated by nutriment, cytokines, and neural signal. Recently, glucagon-like peptide-1 receptor agonists are widely applied in the treatment of type 2 diabetes mellitus. It also has benefits in weight loss, blood pressure reduction and lipid metabolism mediation and heart, kidney protection in addition to steady glucose control when compared with traditional hypoglycemic agents. Research progress on pharmacological action of glucagon-like peptide-1 receptor agonists are reviewed in this paper.

R977

天津市科技计划项目（18YFZCSY00290、19YFZCSY00630）