目的 分析咸阳市中心医院179例丹参川芎嗪注射液的不合理使用情况，为规范临床合理使用提供参考。方法 利用临床用药信息化软件调取2019年8月26日-2019年9月25日使用丹参川芎嗪注射液出院患者179例，参照药品说明书、相关专家共识或文献，从适应症、用法用量、禁忌症、配伍合理性等方面进行点评。结果 使用丹参川芎嗪注射液的患者年龄主要在61~88岁，构成比为51.40%；不合理类型共计124例，其中无适应症用药的有111例，构成比为89.52%；用法用量不合理共5例，单次剂量>10 mL有2例，未单独使用有3例；存在禁忌症5例，快速性心律失常有2例，出血倾向者有3例；存在配伍禁忌有3例，是与10%氯化钾溶液配伍使用。14个科室使用了丹参川芎嗪注射液，神经外科、呼吸内科和急诊医学科的不合理率为100.00%。结论 丹参川芎嗪注射液在临床科室使用中存在不合理现象，需多部门联合采取措施规范其合理应用。

Objective To investigate the unreasonable use of 179 cases of Danshen Chuanxiongqin Injection in Xianyang Central Hospital, and provide a reference for reasonable application of Danshen Chuanxiongqin Injection. Methods A total of 179 cases of inpatients who were administrated with Danshen Chuanxiongqin Injection from August 26, 2019 to September 25, 2019. The rationality was evaluated in terms of indications, usage and dosage, contraindications, repeated medications and others rational aspects, according to the drug instructions and related treatment guidelines or literature. Results Patients using Danshen Chuanxiongqin Injection were 61-88 years old, accounting for 51.40%. There were 124 cases of unreasonable drug use, in which 111 cases had no indication for medication, accounting for 89.52%. There were 5 cases of unreasonable usage and dosage, in which single dose >10 mL had 2 cases and not used alone had 3 cases. There were 5 cases of contraindications with 2 cases of tachyarrhythmia and 3 cases of bleeding tendency. There were 3 cases of incompatibility, and were compatible with 10% KCl solution. Danshen Chuanxiongqin Injection was used in 14 departments. The unreasonable utilization rates of Department of Neurosurgery, Department of Respiratory, and Department of Emergency Medicine were all 100.00%. Conclusion There is an unreasonable phenomenon in the clinical application of Danshen Chuanxiongqin Injection. It is necessary to take measures in multiple departments to regulate its rational application.

R969.3

陕西省中医药管理局2019-2020年度科研立项（2019-ZZ-JC046）