目的 了解河南中医药大学第一附属医院2016-2018年门诊抗组胺药物的使用情况，为临床合理应用提供科学依据。方法 采用回顾性研究方法对2016-2018年河南中医药大学第一附属医院抗组胺药物的销售金额、用药频度（DDDs）、日均费用（DDC）、排序比（B/A）等进行统计分析。结果 2016-2018年抗组胺药物的总金额呈上升趋势，占抗变态反应药总金额的构成比浮动于50%上下。抗组胺药物的品种数保持不变，均为11种。销售金额和DDDs整体呈上升趋势。第2代抗组胺药所占销售金额和DDDs的比例均高，占主导地位。左西替利嗪的销售金额和DDDs连续3年稳居第1位。抗组胺药物的DDC保持相对稳定，左西替利嗪和异丙嗪的B/A为1。结论 2016-2018年河南中医药大学第一附属医院门诊抗组胺药物的品种基本能满足临床需求，抗组胺药物的使用量呈上升趋势，第2代抗组胺药是临床使用的主力军，与各指南推荐相符，基本合理。

Objective To evaluate the utilization of antihistamine agents in Department of Outpatient in the First Affiliated Hospital of Henan University of TCM from 2016 to 2018. Methods The use of antihistamine agents in the First Affiliated Hospital of Henan University of TCM from 2016 to 2018 were analyzed statistically in terms of consumption sum, frequency of drug use (DDDs), defined daily cost (DDC), and drug sequence ratio (B/A), etc. Results Consumption sum of antihistamine drugs maintained an upward trend, and the component ratio of the total amount of antiallergic drugs fluctuated around 50%. The number of antihistamine drugs was remained unchanged with 11. Sales amount and DDDs of antihistamine agents remained on a growth trend. Sales amount and DDDs of the second generation of antihistamine drugs was in the leading position with high constituent ratio. Consumption sum and DDDs of levocetirizine was ranked the first for 3 consecutive years. DDC of antihistamine agents remained relatively stable. B/A of levocetirizine and promethazine were 1. Conclusion The number of antihistamine drugs could meet clinical needs in Department of Outpatient in the First Affiliated Hospital of Henan University of TCM from 2016 to 2018. The use of antihistamines is on the rise. The second generation of antihistamine drugs is the principle force and clinical use is reasonable in the main according with the guidelines.

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