目的 探讨五黄养阴颗粒联合盐酸吡格列酮治疗2型糖尿病的临床疗效。方法 选择2016年5月-2018年9月在淮安市淮安医院治疗的2型糖尿病患者96例，根据用药的差别分为对照组（48例）和治疗组（48例）。对照组口服盐酸吡格列酮片，15~30 mg/次，1次/d；治疗组在对照组基础上口服五黄养阴颗粒，6 g/次，3次/d。两组患者均治疗8周。观察两组患者临床疗效，同时比较治疗前后两组患者空腹血糖（FPG）、餐后2 h血糖（2 h PG）、糖化血红蛋白（HbA1c）、胰岛β细胞功能、超氧化物歧化酶（ROS）、血清尿酸（SUA）和还原型谷胱甘肽（GSH）指标。结果 治疗后，对照组临床有效率为85.42%，显著低于治疗组的91.67%，两组比较差异有统计学意义（P<0.05）。经治疗，两组患者空腹血糖FPG、2 h PG、HbA1c等血糖指标均明显降低（P<0.05），且治疗组患者这些血糖指标比对照组改善更明显（P<0.05）。经治疗，两组患者FINS水平显著降低（P<0.05），而ISI指数和HOMA-IR指数显著升高（P<0.05），且治疗组患者胰岛β细胞功能明显好于对照组（P<0.05）。经治疗，两组患者ROS、SUA显著降低（P<0.05），而GSH显著升高（P<0.05），且治疗组改善程度明显好于对照组（P<0.05）。结论 五黄养阴颗粒联合盐酸吡格列酮片治疗2型糖尿病临床效果良好，降低血糖水平显著，减轻炎症反应，降低肾脏损伤风险，提高患者生活质量。

Objective To investigate the clinical efficiency of Wuhuang Yangyin Granules combined with pioglitazone in treatment of type 2 diabetes. Methods Patients (96 cases) with type 2 diabetes in Huai'an Hospital from May 2016 to September 2018 were divided into control (48 cases) and treatment (48 cases) groups based on different treatments. Patients in the control group were po administered with Pioglitazone Hydrochlorid Tablets, 15-30 mg/time, once daily. Patients in the treatment group were po administered with Wuhuang Yangyin Granules on the basis of the control group, 6 g/time, three times daily. Patients in two groups were treated for 8 weeks. After treatment, the clinical efficacy was evaluated, and FPG, 2 h PG, HbA1c, islet β cell function, ROS, SUA and GSH in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 85.42%, which was significantly lower than 91.67% in the treatment group, and there were differences between two groups (P<0.05). After treatment, FPG, 2 h PG and HbA1c in two groups were significantly decreased, and these glycemic indexes in the treatment group were significantly lower than those in the control group (P<0.05). After treatment, the FINS levels in two groups were significantly decreased (P<0.05), but the ISI and HOMA-IR were significantly increased (P<0.05), and the islet β cell function in the treatment group were significantly better than those in the control group (P<0.05). After treatment, the ROS and SUA levels in two groups were significantly decreased, but the GSH levels were significantly increased (P<0.05), and these indexes in the treatment group were significantly better than those in the control group (P<0.05). Conclusion Wuhuang Yangyin Granules combined with pioglitazone in treatment of type 2 diabetes has good clinical effect, can effectively reduce the blood sugar level, reduce the inflammation and the risk of kidney damage, can also improve the quality of life.

R977