目的 探讨银花泌炎灵片联合注射用头孢噻肟钠治疗急性肾盂肾炎的临床疗效。方法 选择2018年6月-2019年6月在驻马店市中心医院治疗的急性肾盂肾炎患者94例，根据用药的差别分为对照组（47例）和治疗组（47例）。对照组患者静脉滴注注射用头孢噻肟钠，2.0 g加入生理盐水100 mL，2次/d；治疗组在对照组的基础上口服银花泌炎灵片，4片/次，4次/d。两组患者均治疗14 d。观察两组患者临床疗效，同时比较治疗前后两组患者症候积分，血清转化生长因子β1（TGF-β1）、白细胞介素-6（IL-6）、组织型-纤维蛋白溶解酶原激活剂（t-PA）、白细胞介素-17（IL-17）、乙酰-β-D-葡萄糖苷酶（NAG）、β2-微球蛋白（β2-MG）水平，以及SF-36、PSQI和APACHE Ⅱ评分。结果 治疗后，对照组临床有效率为80.85%，显著低于治疗组的97.87%，两组比较差异有统计学意义（P<0.05）。经治疗，两组患者症候积分及SF-36、PSQI和APACHE Ⅱ评分均显著降低（P<0.05），且治疗组患者比对照组降低更明显（P<0.05）。经治疗，两组患者血清β2-MG、IL-6、TGF-β1、IL-17、NAG水平均显著降低（P<0.05），而t-PA水平均明显升高（P<0.05），且治疗组比对照组改善更明显（P<0.05）。结论 银花泌炎灵片联合头孢噻肟治疗急性肾盂肾炎可有效改善患者临床症状，有利于患者生活质量的提高。

Objective To explore the clinical effect of Yinhua Miyanling Tablets combined with cefotaxime in treatment of acute pyelonephritis. Methods Patients (94 cases) with acute pyelonephritis in Zhumadian Central Hospital from June 2018 to June 2019 were divided into control (47 cases) and treatment (47 cases) groups based on different treatments. Patients in the control group were iv administered with Cefotaxime Sodium for injection, 2.0 g added into normal saline 100 mL, twice daily. Patients in the treatment group were po administered with Yinhua Miyanling Tablets on the basis of the control group, 4 tablets/time, 4 times daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacy was evaluated, and the symptom scores, the serum levels of β2-MG, IL-6, TGF-β1, IL-17 and NAG, SF-36, PSQI, and APACHE Ⅱ scores in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 80.85%, which was significantly lower than 97.87% in the treatment group, and there were differences between two groups (P<0.05). After treatment, the symptom scores, SF-36, PSQI, and APACHE Ⅱ scores in two groups were significantly decreased (P<0.05), and these scores in the treatment group were significantly lower than those in the control group (P<0.05). After treatment, the serum levels of β2-MG, IL-6, TGF-β1, IL-17, and NAG in two groups were significantly decreased, but the t-PA levels were significantly increased (P<0.05), and these serological indexes in the treatment group were significantly better than those in the control group (P<0.05). Conclusion Yinhua Miyanling Tablets combined with cefotaxime in treatment of acute pyelonephritis can effectively improve the clinical symptoms and the quality of life of patients.

R983