目的 研究美洛昔康片联合玻璃酸钠注射液治疗膝关节滑膜炎的临床疗效。方法 选取2016年4月—2018年4月四川省骨科医院诊治的120例膝关节滑膜炎患者作为研究对象，采用随机对照表法将患者分为对照组和治疗组，每组各60例。对照组患者给予关节腔内注射玻璃酸钠注射液，25 mg/次，1次/周；治疗组患者在对照组治疗的基础上口服美洛昔康片，1片/次，1次/d。1周为1个疗程，两组患者持续治疗4个疗程。观察两组患者的临床疗效，同时比较两组治疗前后的视觉模拟评分法（VAS）评分、膝关节功能评分（LKSS）和炎性因子水平。结果 治疗后，对照组和治疗组的总有效率分别为80.00%、95.00%，两组比较差异具有统计学意义（P<0.05）。治疗后，两组VAS评分显著降低，LKSS评分显著升高，同组治疗前后比较差异具有统计学意义（P<0.05）；治疗后，治疗组VAS评分和LKSS评分显著优于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者肿瘤坏死因子-α（TNF-α）、白细胞介素-1（IL-1）和白细胞介素-6（IL-6）水平均显著降低，同组治疗前后比较差异具有统计学意义（P<0.05）；治疗后，治疗组炎性因子水平显著低于对照组，两组比较差异具有统计学意义（P<0.05）。结论 美洛昔康片联合玻璃酸钠注射液治疗膝关节滑膜炎具有较好的临床疗效，能缓解患者临床症状，降低血清炎性因子水平，具有一定的临床推广应用价值。

Objective To study the clinical efficacy of Meloxicam Tablets combined with Sodium Hyaluronate Injection in treatment of gonarthromeningitis. Methods Patients (120 cases) with gonarthromeningitis in Sichuan Provincial Orthopedic Hospital from April 2016 to April 2018 were divided into control and treatment groups by random comparison table, and each group had 60 cases. Patients in the control group were intra articular injection administered with Sodium Hyaluronate Injection, 25 mg/time, once weekly. Patients in the treatment group were po administered with Meloxicam Tablets on the basis of control group, 1 tablet/time, once daily. A course of treatment had 1 week, and patients in two groups were treated for 4 courses. After treatment, the clinical efficacy was evaluated, and the VAS scores, LKSS scores, and inflammatory factors levels in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups was 80.00% and 95.00%, respectively, and there were differences between two groups (P<0.05). After treatment, VAS scores in the two groups were significantly decreased, but LKSS scores were significantly increased, and there were differences in the same group (P<0.05). After treatment, VAS and LKSS scores in the treatment group were significantly better than those in the control group, and there were differences between two groups (P<0.05). After treatment, the levels of TNF-α, IL-1, and IL-6 in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). After treatment, the inflammatory factors levels in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). Conclusion Meloxicam Tablets combined with Sodium Hyaluronate Injection has good effect in treatment of gonarthromeningitis, can alleviate the clinical symptoms of patients, and reduce the serum inflammatory factors level, which has a certain clinical application value.