目的 探讨复方菝葜颗粒联合DP方案（顺铂＋多西他赛）治疗晚期宫颈癌的临床疗效。方法 选取2016年7月—2017年1月西南医科大学附属医院收治的晚期宫颈癌患者94例为研究对象，按治疗方案将患者分为对照组和治疗组，每组47例。对照组给予DP方案化疗，静脉滴注多西他赛注射液70 mg/m²，1次/周；同时于每个周期的第1天静脉滴注注射用顺铂70 mg/m²。治疗组在对照组治疗基础上口服复方菝葜颗粒，1袋/次，3次/d。21 d为1个化疗周期，两组患者均连续治疗4个周期。观察两组的临床疗效，比较两组的生活质量、毒副作用。结果 治疗后，对照组和治疗组的客观缓解率分别为48.9%、72.3%，疾病控制率分别为70.2%、89.4%，两组比较差异有统计学意义（P<0.05）。治疗后，两组社会/家庭状况评分、附加关注评分、情感状况评分、生理状况评分、功能状况评分和总评分均显著升高，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组生活质量评分明显高于对照组，两组比较差异有统计学意义（P<0.05）。治疗期间，治疗组轻度转氨酶增高、腹痛腹泻、恶心呕吐、白细胞计数降低、血红蛋白降低、血小板降低的发生率均明显低于对照组，两组比较差异有统计学意义（P<0.05）。随访期间，对照组和治疗组1年生存率分别为76.6%、87.2%，2年生存率分别为63.8%、74.5%，两组比较差异有统计学意义（P<0.05）。结论 复方菝葜颗粒联合DP方案治疗晚期宫颈癌具有较好的临床疗效，可改善患者的生活质量，提高1、2年生存率，毒副作用小，具有一定的临床推广应用价值。

Objective To investigate the clinical effect of Compound Baqia Granules combined with DP regimen in treatment of advanced cervical cancer. Methods Patients (94 cases) with advanced cervical cancer in the Affiliated Hospital of Southwest Medical University from July 2016 to January 2017 were enrolled in this study. According to the difference treatment plan, patients were randomly divided into control and treatment groups, and each group had 42 cases. Patients in the control group were given DP regimen:patients were iv administered with Docetaxel Injection, 70 mg/m², once weekly, and patients were also iv administered with Cisplatin for injection at the first day per cycle, 70 mg/m². Patients in the treatment group were po administered with Compound Baqia Granules on the basis of the control group, 1 bag/time, three times daily. A chemotherapy cycle had 21 d, and patients in two groups were treated for 4 cycles. After treatment, the clinical efficacies were evaluated, and quality of life and toxic reactions in two groups were compared. Results After treatment, the objective remission rates in the control and treatment groups were 48.9% and 72.3%, respectively, and the disease control rates in the control and treatment groups were 70.2% and 89.4%, respectively, and there was difference between two groups (P<0.05). After treatment, the scores of social/family status, additional concern, emotional status, physiological status, and functional status and total scores in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the quality of life scores in the treatment group were significantly higher than those in the control group, with significant difference between two groups (P<0.05). During treatment, the incidence rates of mild elevation of transaminase, abdominal pain, diarrhea, nausea and vomiting, decrease of white blood cell count, decrease of hemoglobin and decrease of platelet in the treatment group were significantly lower than those in the control group, and there was difference between two groups (P<0.05). During the follow-up period, the 1-year survival rates in the control and treatment groups were 76.6% and 87.2%, respectively, and the 2-year survival rates in the control and treatment groups were 63.8% and 74.5%, respectively, and there was difference between two groups (P<0.05). Conclusion Compound Baqia Granules combined with DP regimen has clinical curative effect in treatment of advanced cervical cancer, can improve the quality of life of patients, increase the survival rate of 1 and 2 years, with less toxicity, which has a certain clinical application value.