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[摘要]
目的 探讨肾衰宁颗粒联合缬沙坦治疗早期糖尿病肾病的临床疗效。方法 选取汉中市铁路中心医院2016年8月—2018年6月收治的早期糖尿病肾病患者110例,随机分为对照组和治疗组,每组各55例。对照组患者口服缬沙坦胶囊,1粒/次,1次/d。治疗组在对照组基础上口服肾衰宁颗粒,1袋/次,3次/d。两组患者均连续治疗2个月。观察两组患者临床疗效,同时比较治疗前后两组患者氧化应激指标、血清胱抑素C(Cys-c)、晚期糖基化终产物(AGEs)、白介素-8(IL-8)、尿白蛋白尿排泄率(UAER)/24 h、尿素氮(BUN)、血肌酐(Scr)、空腹血糖(FPG)和糖化血红蛋白(HbA1c)水平。结果 治疗后,对照组和治疗组临床有效率分别为78.18%、90.91%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者超氧化物歧化酶(SOD)水平显著上升(P<0.05),晚期氧化蛋白产物(AOPP)、Cys-c、AGEs、IL-8、UAER/24 h、BUN、Scr、FPG和HbA1c水平显著下降,同组治疗前后比较差异具有统计学意义(P<0.05);且治疗后治疗组这些指标水平明显好于对照组,两组比较差异具有统计学意义(P<0.05)。结论 肾衰宁颗粒联合缬沙坦可有效的减轻早期糖尿病肾病患者氧化应激及炎症反应,降低血糖,改善肾功能。
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[Abstract]
Objective To explore the curative effect of Shenshuaining Granules combined with valsartan in treatment of early diabetic nephropathy. Methods Patients (110 cases) with early diabetic nephropathy in Hanzhoung Railway Central Hospital from August 2016 to June 2018 were randomly divided into control and treatment groups, and each group had 55 cases. Patients in the control group were po administered with Valsartan Capsules, 1 grain/time, once daily. Patients in the treatment group were po administered with Shenshuaining Granules on the basis of the control group, 1 bag/time, three times daily. Patients in two groups were treated for 2 months. After treatment, the clinical efficacy was evaluated, and the oxidative stress indexes, Cys-c, AGEs, IL-8, UAER/24h, BUN, Scr, FPG, and HbA1c levels in two groups before and after treatment were compared. Results After treatment, the clinical efficacy and in the control and treatment groups was 78.18% and 90.91% respectively, and there were differences between two groups (P<0.05). After treatment, the SOD levels in two groups were significantly increased, but the AOPP, Cys-c, AGEs, IL-8, UAER/24h, BUN, Scr, FPG and HbA1c levels were significantly decreased, and the difference was statistically significant in the same group (P<0.05), and these indicators levels in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). Conclusion Shenshuaining Granules combined with valsartan in treatment of early diabetic nephropathy can effectively alleviate oxidative stress and inflammation, and reduce blood sugar, improve the renal function.
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