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[摘要]
目的 研究温胃舒颗粒联合铝碳酸镁治疗慢性浅表性胃炎的临床疗效。方法 选取2018年1月—2019年1月来中国人民解放军联勤保障部队第九0一医院就诊的慢性浅表性胃炎患者101例,根据入院先后分成对照组(50例)和治疗组(51例)。对照组口服铝碳酸镁片,2片/次,3次/d。治疗组患者在对照组治疗基础上口服温胃舒颗粒,1袋/次,2次/d。两组患者均连续治疗4周。观察两组的临床疗效,比较两组治疗前后证候积分、胃黏膜炎性病变评分、日常生活能力评分、血清列腺素E2(PGE2)和超氧化物歧化酶(SOD)的变化情况。结果 治疗后,对照组和治疗组的总有效率分别是82.00%、96.08%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者证候积分、胃黏膜炎性病变评分均较治疗前显著降低,而日常生活能力评分明显升高,同组治疗前后比较差异具有统计学意义(P<0.05);治疗后,治疗组证候积分、胃黏膜炎性病变评分低于对照组,而日常生活能力评分高于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者血清PGE2、SOD水平均明显升高,同组治疗前后比较差异具有统计学意义(P<0.05);治疗后,治疗组PGE2、SOD水平显著高于对照组,两组比较差异具有统计学意义(P<0.05)。结论 温胃舒颗粒联合铝碳酸镁治疗慢性浅表性胃炎疗效显著,能明显改善患者的临床症状,修复损伤胃黏膜,具有一定的临床推广应用价值。
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[Abstract]
Objective To investigate the clinical efficacy of Wenweishu Granules combined with hydrotalcite in treatment of chronic superficial gastritis. Methods Patients (101 cases) with chronic superficial gastritis in 901th Hospital of PLA Joint Logistics Support Force from January 2018 to January 2019 were divided into control (50 cases) and treatment (51 cases) groups based on admission orders. Patients in the control group were po administered with Hydrotalcite Tablets, 2 tablets/time, three times daily. Patients in the treatment group were po administered with Wenweishu Granules on the basis of the control group, 1 bag/time, twice daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacy was evaluated, and the changes of syndrome score, gastric mucosa inflammatory lesion score, daily living ability score, PGE2 and SOD in two groups before and after treatment were compared. Results After treatment, the angina pectoris efficacy in the control and treatment groups were 82.00% and 96.08%, respectively, and there were differences between two groups (P<0.05). After treatment, syndrome score, gastric mucosa inflammatory lesion score in two groups were significantly decreased, but daily living ability score in two groups were significantly increased, and there were differences in the same group (P<0.05). After treatment, syndrome score and gastric mucosa inflammatory lesion score in the treatment group were significantly lower than those in the control group, but daily living ability score was higher than that in the control group, and and there were differences between two groups (P<0.05). After treatment, PGE2 and SOD in two groups were significantly increased, and there were differences in the same group (P<0.05). After treatment, PGE2 and SOD in the treatment group were significantly higher than those in the control group, and there were differences between two groups (P<0.05). Conclusion Wenweishu Granules combined with hydrotalcite has significant effect in treatment of chronic superficial gastritis, and can significantly improve the clinical symptoms, and also can repair damaged gastric mucosa, which has a certain clinical application value.
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