目的 探讨巴戟天寡糖胶囊联合阿戈美拉汀片治疗老年抑郁症的临床疗效。方法 选取2015年7月—2018年7月内蒙古自治区人民医院收治的187例老年抑郁症患者作为研究对象，所有患者根据入院顺序随机分成巴戟天寡糖胶囊组（62例）、阿戈美拉汀组（62例）和联合治疗组（63例）。巴戟天寡糖胶囊组患者口服巴戟天寡糖胶囊，1粒/次，2次/d；阿戈美拉汀组患者于睡前口服阿戈美拉汀片，1片/次，1次/d；联合治疗组采用巴戟天寡糖胶囊联合阿戈美拉汀片进行治疗，剂量与巴戟天寡糖胶囊组、阿戈美拉汀组相同。3组患者均连续治疗6周。观察3组的临床疗效，比较3组的汉密尔顿焦虑评分、汉密尔顿抑郁评分、血清肿瘤坏死因子-α（TNF-α）和白细胞介素1β（IL-1β）水平。结果 治疗后，巴戟天寡糖胶囊组、阿戈美拉汀组和联合治疗组的总有效率分别为83.87%、85.48%、96.83%，组间比较差异具有统计学意义（P<0.05）。治疗后，3组患者汉密尔顿焦虑评分和汉密尔顿抑郁评分均显著降低，同组治疗前后比较差异具有统计学意义（P<0.05）；且联合治疗组汉密尔顿焦虑评分和汉密尔顿抑郁评分显著低于巴戟天寡糖胶囊组和阿戈美拉汀组，组间比较差异具有统计学意义（P<0.05）。治疗后，3组患者血清TNF-α和IL-1β水平均显著降低，同组治疗前后比较差异具有统计学意义（P<0.05）；且联合治疗组血清TNF-α和IL-1β水平均显著低于巴戟天寡糖胶囊组和阿戈美拉汀组，组间比较差异具具有显著性（P<0.05）。结论 巴戟天寡糖胶囊联合阿戈美拉汀片治疗老年抑郁症具有较好的临床疗效，能改善临床症状，调整血清因子水平，安全性较好，具有一定的临床推广应用价值。

Objective To investigate the efficacy of Bajitian Oligosaccharide Capsules combined with Agomelatine Tablets in treatment of senile depression. Methods Patients (187 cases) with senile depression in Inner Mongolia People's Hospital from July 2015 to July 2018 were randomly divided into Bajitian Oligosaccharide Capsules group (62 cases), Agomelatine Tablets group (62 cases) and the combined treatment group (63 cases). Patients in Bajitian Oligosaccharide Capsules group were po administered with Bajitian Oligosaccharide Capsules, 1 grain/time, twice daily. Patients in Agomelatine Tablets group were po administered with Agomelatine Tablets, 1 tablet/time, once daily. Patients in the combined treatment group were po administered with Bajitian Oligosaccharide Capsules and Agomelatine Tablets, and the dosage was the same as above. Patients in two groups were treated for 6 weeks. After treatment, the clinical efficacies were evaluated, and Hamilton anxiety scores, Hamilton depression scores, serum levels of TNF-α and IL-1β in three groups were compared. Results After treatment, the clinical efficacies in Bajitian Oligosaccharide Capsules, Agomelatine Tablets, and combined treatment groups were 83.87%, 85.48% and 96.83%, respectively, and there was difference among three groups (P<0.05). After treatment, Hamilton anxiety scores and Hamilton depression scores in three groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the combined treatment group were significantly lower than those in Bajitian Oligosaccharide Capsules and Agomelatine Tablets group, with significant difference among three groups (P<0.05). After treatment, the levels of TNF-α and IL-1β in three groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the combined treatment group were significantly lower than those in Bajitian Oligosaccharide Capsules and Agomelatine Tablets group, with significant difference among three groups (P<0.05). Conclusion Bajitian Oligosaccharide Capsules combined with Agomelatine Tablets has clinical curative effect in treatment of senile depression, can improve clinical symptoms, and adjust serum factor levels, with good safety, which has a certain clinical application value.