目的 探讨川芎清脑颗粒联合托吡酯片治疗偏头痛的临床疗效。方法 选取2016年5月—2018年5月重庆市梁平区人民医院收治的182例偏头痛患者作为研究对象，随机将患者分为对照组和治疗组，每组各91例。对照组口服托吡酯片，25 mg/d，维持1周；第2周25 mg/次，2次/d；第3周早上25 mg，晚上50 mg；第4周50 mg/次，2次/d。治疗组在对照组治疗的基础上冲服川芎清脑颗粒，10 g/次，3次/d。两组患者均连续治疗8周。观察两组患者的临床疗效，比较两组治疗前后的临床症状改善情况、神经元放电情况和血液流变学指标。结果 治疗后，对照组和治疗组的总有效率分别为76.9%、95.6%，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者偏头痛发作频率和持续时间均明显下降（P<0.05）；治疗后，治疗组发作频率、持续时间均显著短于对照组（P<0.05）。治疗后，治疗组α波频率变慢、δ波增多和θ波增多比例均显著高于对照组（P<0.05）。治疗后，两组患者血浆黏度（PV）、全血高切黏度（WBHSV）、全血低切黏度（WBLSV）、红细胞压积（HCT）和纤维蛋白原（FIB）水平均明显下降（P<0.05）；治疗后，治疗组血液流变学指标均显著低于对照组（P<0.05）。结论 川芎清脑颗粒联合托吡酯片治疗偏头痛具有较好的临床疗效，可有效改善患者的神经元放电和血液流变学指标，具有一定的临床推广应用价值。

Objective To investigate the therapeutic effect of Chuanxiong Qingnao Granules combined with Topiramate Tablets in treatment of migraine. Methods Patients (182 cases) with migraine in Chongqing Liangping District People's Hospital from May 2016 to May 2018 were randomly divided into control and treatment groups, and each group had 91 cases. Patients in the control group were po administered with Topiramate Tablets 25 mg/d for the first week, and 25 mg/time for the second week, twice daily. And 25 mg in the morning and 50 mg in the evening for the third week, and 50 mg/time, twice daily for the fourth week. Patients in the treatment group were po administered with Chuanxiong Qingnao Granules on the basis of control group, 10 g/time, three times daily. Patients in two groups were treated for 8 weeks. After treatment, the clinical efficacy was evaluated, and the improvements of clinical symptoms, neuronal discharges, hemorheological indexes, adverse reactions in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups was 76.9% and 95.6%, respectively, and there were differences between two groups (P<0.05). After treatment, the frequency and duration of migraine attacks in the two groups were significantly decreased (P<0.05). After treatment, the frequency and duration of migraine attacks in the treatment group were significantly lower than those in the control group (P<0.05). After treatment, the ratio of α wave frequency slowed down, δ and θ wave increased in treatment group were significantly higher than those in the control group (P<0.05). After treatment, the levels of PV, WBHSV, WBLSV, HCT, and FIB in two groups were significantly decreased (P<0.05). After treatment, the hemorheological index levels in the treatment group were significantly lower than those in the control group (P<0.05). Conclusion Chuanxiong Qingnao Granules combined with Topiramate Tablets has a good effect in treatment of migraine, can effectively improve the neuronal discharges and the hemorheological indexes, which has a certain clinical application value.